t authority, FDA is the most powerful consumer protection agency in the world. This course will familiarize students with FDA’s mission, philosophy and organizational structure, as well as policy and procedure it uses to ensure the safety and effectiveness of the food, drugs, biologics, cosmetics, medical devices and radiation-emitting products it regulates. Recommended preparation: Enrollment in the MEM Biomedical Entrepreneurship Track. Offered as BIOS 447, HSMC 447, and IIME 447.
IIME 450A. Engineering Entrepreneurship I (3)
The nature and importance of entrepreneurship is an area of importance to business leaders, educators, politicians, and individual members of the society. It is a driver of economic development and wealth creation in organization units ranging in size from the individual company to entire nations. Technology-based entrepreneurship is particularly important to this economic development due to its impact on productivity and its potential for exponential growth. To create something new and of value to both the organization and the market requires a technical individual who is willing to assume the social, psychic, and financial risks involved and achieve the resulting rewards whether these be monetary, personal satisfaction, or independence. This can occur while starting an enterprise (i.e., entrepreneurship) or while driving innovation in an existing organization (intrapreneurship). This course will also take students through a variety of issues related to enhancing innovation in the context of a technology-based organization. This is sometimes termed intrapreneurship and includes innovating new products and services within an organization. This is a very complex field and relatively young. Students will learn that there are not many “absolute truths,” but there are numerous best practices and benchmarks that can assist the intrapreneur. Recommended preparation: accredited bachelor’s degree in engineering plus summer job experience.
IIME 450B. Engineering Entrepreneurship II (3)
IIME 470. Independent Projects (3)
This course is designed for students wishing to expand experiential learning opportunities at the interface of engineering and management. Preferred focus areas in entrepreneurship and opportunity assessment, product design and development, and manufacturing planning and management. Project ideas along with milestone, deliverables, and potential corporate clients need to be arranged in advance.
Master of Science Degree Programs
Recognizing the different needs and objectives of resident and non-resident graduate students pursuing the master’s degree, two different plans are offered. In both plans, transfer of credit from another university is limited to six hours of graduate-level courses, taken in excess of the requirements for an undergraduate degree, approved by the student’s advisor, the department chair, and the dean of graduate studies.
All Master of Science degree programs require the submission of a Planned Program of Study which must be approved by the engineering department and the dean of graduate studies, and which must be submitted before registering for the last 9 course credits of the program.
Master’s Thesis Plan
Minimum requirements for the degree of Master of Science in a major field under this plan are:
At least 18 hours of total course work, including up to 9 hours of thesis research, must be at the 400 level or higher.
Master’s Comprehensive Plan
Students may pursue either a project or non-project track under this option. Minimum requirements for the degree of Master of Science in a major field under this plan are
UNDESIGNATED MASTER OF SCIENCE DEGREE
A student working toward an undesignated Master of Science degree in engineering must select a department. The student is responsible for submitting a Planned Program of Study, which must have the approval of the engineering department and the dean of graduate studies, and which must contain a minimum of 9 semester hours of course work in the department approving the program. A minimum of 18 semester hours of course work for the degree must be at the 400 level or higher. The student must meet all the requirements of the designated Master of Science degree in engineering.
Doctor of Philosophy Degree
The student’s Ph.D. program should be designed to prepare him or her for a lifetime of creative activity in research and in professional engineering practice. This may be coupled with a teaching career. The mastery of a significant field of knowledge required to accomplish this purpose is demonstrated by an original contribution to knowledge embodied in a thesis and by satisfactory completion of a comprehensive course program which is intensive in a specific area of study and includes work in other areas related to, but not identical with, the major field. The necessity for breadth as well as depth in the student’s education cannot be overemphasized. To this end, any engineering department may add additional requirements or constraints to ensure depth and breadth appropriate to its field.
No student may be admitted to candidacy for the Ph.D. degree before approval of his or her Planned Program of Study by the Advisory Committee and the engineering department. After this approval has been obtained, it is the responsibility of the student’s department to notify the dean of graduate studies of his or her admission to candidacy after the student has fulfilled any additional department requirements. Minimal requirements in addition to the university requirements are
The student must pass a qualifying examination relevant to his or her area of study as designated by the curricular department with which he or she is affiliated. For students who obtain the M.S. degree from Case Western Reserve University, the qualifying examination should be taken preferably before the end of the student’s fourth semester of graduate study but no later than the end of the fifth semester at the university. For students entering with the master’s degree the examination should be taken no later than the end of the third semester at the university.
Planned Program of Study
Each student is required to submit a Planned Program of Study, detailing his or her course work, thesis schedule, and qualifying examination schedule and indicating that all the minimum requirements of the university and the faculty of the Case School of Engineering are satisfied. This Planned Program of Study must be approved by the advisory committee and the engineering department before registering for the last 18 credits hours of the program.
If the student is pursuing the Ph.D. degree without acquiring the M.S. degree, a petition to waive the requirement of the M.S. degree should be approved by the departmental advisor, the chair and submitted to the dean of graduate studies. All required courses taken at the university beyond the B.S. degree should be shown on the Planned Program of Study with the grade if completed. If the requirements are to be fulfilled in other than the standard ways described above, a memorandum requesting approval should be submitted to the dean of graduate studies.
The Planned Program of Study must be submitted within one semester after passing the qualifying examination.
Interdisciplinary Research Centers
Interdisciplinary research centers act as intensive incubators for students and faculty doing research and studying applications in specialized areas. Thirteen research centers and research programs at the Case School of Engineering have been organized to pursue cutting-edge research in collaboration with industrial and government partners. The transfer of technology to industry is emphasized in all the centers.
The educational programs of these centers encompass the training of graduate students in advanced methods and strategies, thus preparing them to become important contributors to industry after graduation; the involvement of undergraduates in research; the presentation of seminars that are open to interested members of the community; and outreach to public schools to keep teachers abreast of scientific advances and to kindle the interest of students in seeking careers in engineering.
Advanced Platform Technology (APT) Center
Louis Stokes Cleveland Veterans Affairs
10701 East Boulevard, Mail Stop 151
Cleveland, Ohio 44106
Phone: 216-707-6421 Fax: 216-707-6420
Ronald J. Triolo, Executive Director
The Advanced Platform Technology (APT) Center brings together top faculty and researchers from Case Western Reserve University and the Cleveland Veteran’s Affair Medical Center to capture the most recent developments in the fields of microelectronics and material science and focus them on the practical medical needs of individuals disabled by sensorimotor dysfunction or limb loss. The APT Center creates novel, cross-cutting technologies for the diagnosis, treatment or study of high priority clinical conditions within a structured framework that facilitates regulatory compliance, outsourcing by contract manufacturers, and dissemination within the rehabilitation community. Center projects to date have concentrated primarily on developing new materials and microsystems for interfacing with the nervous system, repairing orthopaedic trauma and accelerating wound healing, replacing or restoring natural limb, somatosensory and organ system function, and both monitoring and promoting neurological, genito-urinary and vascular health.
The APT Center was established as a VA RR&D Center of Excellence in 2005 and is based at the Louis Stokes Cleveland VAMC (CVAMC). The Center is able to provide the following resources for developing, testing and implementing neural interfaces: 1) manufacture and supply of nerve- and muscle-based stimulating and recording electrodes 2) neural modeling and analysis of interface designs 3) polymer and bioactive material development 4) Microelectromechanical (MEMS) systems design and fabrication 5) rapid prototyping 6) pre-clinical in vitro and in vivo verification of electrode and neural interface performances 8) circuit and software design and 9) system validation and design control documentation.
Case Advanced Power Institute (CAPI)
124 A.W. Smith Building (7217)
Phone: 216-368-2472 Fax: 216-368-0953
Thomas A. Zawodzinski, Director
The Case Advanced Power Institute (CAPI) is a center for research, education, industry stimulation and outreach activities in energy efficient technologies. The current focus is on various fuel cell technologies. CAPI combines the strengths and legacy of fuel cell related research and development at Case Western Reserve University with new generation of leading scientists and engineers. Specifically CAPI R&D is focused on enabling the commercialization of fuel cells. CAPI activities range from studying the fundamentals of the phenomena taking place within the fuel cell to completing performance and system level studies and mathematical modeling. The CAPI Affiliates Program gives industry the opportunity to work directly with expert fuel cell researchers and state-of-the-art capabilities, at below standard rates. Affiliates are consulted on topic areas critical to CAPI research and have access to results from the research program.
Center for Cardiovascular Biomaterials (CCB)
202 Wickenden Building (7207)
Phone: 216-368-3005 Fax: 216-368-4969
Roger E. Marchant, Director
Anirban Sen Gupta, Associate Director
Phone: 216-368-4564 Fax 216-368-4969
The Center for Cardiovascular Biomaterials (CCB) carries out research and development projects to investigate new biomaterials, tissue engineered materials, and targeted drug delivery systems, for use in cardiovascular applications and implants. CCB also provides researchers access to shared use facilities, which includes high resolution microscopy such as AFM, molecular spectroscopies, surface analysis, and polymer and peptide synthesis capabilities. The chemical and mechanical interface between the biomaterial and the host tissue are the focus of major study, with the goals being to improve biologic function and biocompatibility in the response of the human body to implants. Current projects include investigation of thrombosis (blood clotting) and infection mechanisms due to cardiovascular prosthesis, biomimetic design of novel biomaterials for cardiovascular and neural implants; cardiovascular and neural tissue engineering based on biomimetic designs. Studies at the cell and molecular level assist our understanding of the underlying mechanisms, so that novel biomedical materials may be designed, prepared, and characterized.
Center for In Situ Cell and Tissue Imaging
Department of Biomedical Engineering
Phone: 216-368-5884 Fax 216-368-4969
Melissa Knothe Tate, Director
The Center for In Situ Cell and Tissue Imaging (CISCTI) is designed to offer state of the art and cutting edge imaging capabilities to the biomedical community at Case Western Reserve University. The center showcases a custom-configured instrument based on the Leica TCS SP2 AOBS Spectral confocal microscope system (Leica Microsystems, Mannheim, Germany. The tunable acousto-optical beam splitter (AOBS) provides selection and examination of any portion of the visible and near-IR emission wavelengths set for a given dye or chosen for unique research applications; it allows for spectroscopy at length scales from tissue to cellular to subcellular. The microscope is configured with software for fluorescence recovery after photobleaching (FRAP), which provide diffusion rates of fluorescence-marked macromolecules. The upright design of the microscope allows not only examination of slides and cell cultures, but also thicker, opaque objects. The removable stage allows use of large objects, with the confocal scanning feature still functional, because it is built into the motorized nosepiece and not into a motorized stage as in other confocal microscopes. For example, the system allows for live animal and/or cell imaging concomitant fluorescent spectroscopy, patch clamping, fluorescence recovery after photobleaching (FRAP), tracking of molecular transport (e.g. drug delivery), and digital video documentation. In order to assist in preparation of specimens for imaging, a state of the art histology core lab (part of CISCTI) is set up to carry out fixation, embedding, and sectioning of soft and hard tissues. Through a Ohio Board of Regents BRTT grant (Clinical Tissue Engineering Center, CTEC), the CISCTI has recently acquired a stereolithography rapid prototyping system (3D Systems Viper si2).
Center for Layered Polymeric Systems (CLiPS)
NSF Science and Technology Center
420 Kent Hale Smith Building
2100 Adelbert Road
Cleveland, Ohio 44106-7202
Phone: 216-368-4203 Fax: 216-368-6329
Eric Baer, Director
Anne Hiltner, Co-Director
Exploration of multilayered polymeric systems at the micro- and nano-layer levels reveals unique properties and capabilities that are different, and often not predicted, from systems involving the same materials on a larger scale. Technology refined within CLiPS allows the production of films and membranes composed of hundreds or thousands of layers. These extremely thin layers promote interactions approaching the molecular level between the materials used in the process.
CLiPS research focus includes four major areas: the enabling technology which is the continuing refinement of and innovation in the multilayering process; exploration of membranes and transport phenomena for applications such as food and electronic packaging, drug delivery, and diagnostic devices; optic and electronic systems which involves exploring applications in information, electronic and laser technologies; and science and technology initiatives which is directed toward innovation with multilayer technology to create new polymeric structures.
CLiPS was established in 2006 with funding by the National Science Foundation as a Science and Technology Center. It is the first NSF STC ever to be established at Case Western Reserve University. CLiPS is a national center involving close partnership with the University of Texas, Fisk University, the University of Southern Mississippi, and the Naval Research Laboratory, and an important educational partnership with the Cleveland Metropolitan School District.
CLiPS researchers and educators work together to accomplish the Center’s mission of advancing the nation’s science and technology agenda through development of new materials and materials systems and for educating a diverse American workforce through interdisciplinary education programs.
Center for Modeling Integrated Metabolic Systems (MIMS)
410 Wickenden (7207)
Phone: 216-368-4066 Fax:216-368-4969
Gerald M. Saidel, Director
The thrust of the MIMS Center is mathematical modeling and simulation of metabolic systems in response to stresses associated with hypoxia, exercise, diet, and drug inputs. A general integrative whole-body model relates cellular to tissue metabolism with special emphasis on skeletal muscle, and heart. Biomedical research projects incorporate one or more of the metabolic stresses in which the modeling can help quantify mechanisms and predict responses that cannot be directly measured. These projects involve modeling of cell-tissue integration within an organ as well as modeling the integrated, whole-body effects of the combined tissue-organ systems. Critical experimental studies with each of the tissue-organ systems are conducted for model validation. A quantitative understanding of the complexity of cellular metabolism integrated with tissue, organ, and whole-body processes requires sophisticated mathematical models, computer simulations, and validation with experimental data. Physiologically based models incorporate cellular metabolic reactions and transport processes of a large number of chemical species. Such models allow quantitative evaluation of metabolic pathways and regulatory mechanisms under normal and abnormal conditions and associated with disease states. Consequently, these models can provide a basis for simulating the integrated effects of altering enzyme contents/activities or substrate concentrations with pharmacological agents.
Cleveland Functional Electrical Stimulation Center
11000 Cedar Avenue, Suite 230
Cleveland, Ohio 44106-3052
Phone :216-231-3257 Fax: 216-231-3258
P. Hunter Peckham, Director
Functional electrical stimulation (FES) is the application of electrical currents to either generate or suppress activity in the nervous system. FES can produce and control the movement of otherwise paralyzed limbs, for standing and hand grasp; activate visceral bodily functions, such as micturition; create perceptions such as skin sensibility; arrest undesired activity, such as pain or spasm; and facilitate natural recovery and accelerate motor relearning. FES is particularly powerful and clinically relevant, since many people with neurological disabilities retain the capacity for neural conduction, and are thus amenable to this intervention.
The Center focuses its activities in four major areas; Fundamental studies to discover new knowledge; Enabling technologies for clinical application or the discovery of knowledge; Clinical research that applies this knowledge and technology to individuals with neurological dysfunction; Transfer of knowledge and technology to the clinical community and to industry.
The FES Center was established as a VA RR&D Center of Excellence in 1991 and is based at the Louis Stokes Cleveland VAMC (CVAMC). The Center is a consortium with three institutional partners: CVAMC, Case Western Reserve University (CWRU), and the MetroHealth Medical Center (MHMC). The Center accomplishes its mission by integrating and facilitating the efforts of scientists, engineers, and clinicians through common goals and directions in the major clinical areas, and by providing mechanisms to accomplish these goals across the institutional partners.
Electronics Design Center (EDC)
112 Bingham (7200)
Phone: 216-368-2935 Fax: 216-368-8738
Chung-Chiun Liu, Director
The Electronics Design Center (EDC) is a multi-disciplinary educational and research Center focusing on the applications of microfabrication processing to the advancement of chemical and biological micro-systems. The Center has complete thick film and thin film processing facilities, including screen printing, ink jet printing and sputtering equipments. Other facilities supporting the microfabrication processing are also readily available.
Microfabrication Laboratory (MFL)
112 Bingham Building (7200)
Phone: 216-368-2934 Fax: 216-368-8738
Chung-Chiun Liu, Director
MFL houses a state-of-the-art facility that provides the latest in microfabrication and micromachining processes. The Institute focuses on the applications of microfabrication and micromachining technology to a wide range of sensors, actuators and other microelectromechanical (MEMS) systems. Application thrusts include: (i) healthcare; (ii) industrial control, automation and fault detection; (iii) portable power generation; and (iv) functional materials and structures. In addition to silicon based technology, the Institute has a unique strength in silicon carbide micromachining that is particularly valuable for applications in harsh environments. Undergraduate students, graduate students, and post-doctoral assistants use the Institute’s facilities to carry out their research or special projects. Recent developments by researchers in MFL include Schottky diode based hydrogen sensor, high temperature oxygen sensor, nano-structure tin oxide sensor, inertial sensors, micro-size pressure sensors, wireless telemetric microsystems, miniature displays, micromechanical light modulators, microvalves, and micropumps.
MFL facilities support a state-wide network, Ohio MEMSNet, for MEMS research and development.
National Center for Space Exploration Research (NCSER)
305 Olin Building
Phone: 216-368-0748 Fax: 216-368-0718
J. Iwan D. Alexander, Director
The National Center for Space Exploration Research (NCSER) is a collaborative effort between the Universities Space Research Association (USRA), Case Western Reserve University (CWRU), and NASA Glenn Research Center (GRC) that provides GRC with specialized research and technology development capabilities essential to sustaining its leadership role in NASA missions. Expertise resident at NCSER includes reduced gravity fluid mechanics, reduced gravity combustion processes; heat transfer, two-phase flow, micro-fluidics, and phase change processes; computational multiphase fluid dynamics, heat and mass transfer, computational simulation of physico-chemical fluid processes and human physiological systems. This expertise has been applied to:
Neural Engineering Center
112 Wickenden (7207)
Phone: 216-368-3974 Fax: 216-368-4872
Dominique Durand, Director
The research mission of the center is to bring to bear combined tools in physics, mathematics, chemistry, engineering and neuroscience to analyze the mechanisms underlying neuronal function and to solve the clinical problems associated with neuronal dysfunction. Research areas include: Neuromodulation, Neuroprostheses, Quantitative Neurophysiology, Neural Dynamics, Neuro-Mechanical Systems, Neural Regeneration, Neural Interfacing, Neural Imaging and Molecular Sensing, Neuro-Magnetism, and Systems Neuroscience. The education mission of the center is to provide engineers and scientists with an integrated knowledge of engineering and neuroscience capable of solving problems in neuroscience ranging from the molecules to the clinic. The center is also an outlet for technology transfer of new ideas to be commercialized by industrial partners. The center’s goals are accomplished by fostering interdisciplinary research between clinicians, scientists, students and local industry, educational experiences including didactic material, laboratory experience and clinical exposure, and close ties to industrial partners.
ThinkTank for Multiscale Computational Modeling of Bio-medical and Bio-inspired Systems
Department of Mechanical & Aerospace Engineering
10900 Euclid Avenue
Phone: 216-368-5884 Fax: 216-368-4969
Melissa Knothe Tate, Director
Christopher Hernandez, Vice Director
Typically, computational modelers share common approaches to diverse research and development problems. By providing a common space and infrastructure (software licenses and hardware) for computational modelers to work, we hope to promote exchange of modeling experience and expertise and to promote cross-departmental as well as cross-institutional collaborations. The ThinkTank provides a home for several international computational collaborations as well.