Provocative Questions 2015 - 2016
I say success because Ed Harlow, PhD, Professor at the Dana-Farber/Harvard Cancer Center and special advisor to the NCI director, came to our cancer center in December and spent a full day with around 20 of our cancer center members to review and "think tank" about new provocative equations.
A number of the questions look to me like those that we raised in our conversations. So, our center played a significant role helping refine the questions and placing them in the mainstream of NCI thinking.
Please note that there will be a few submission deadlines for these PQs. I encourage you to take these questions on, to collaborate, and to develop a well vetted application. Any of the program and executive committee members will be glad to look over a proposal.
What molecular mechanisms influence disease penetrance in individuals who inherit a cancer susceptibility gene?
PQ - 6
What are the underlying molecular mechanisms that are responsible for the functional differences between benign proliferative diseases and premalignant states?
PQ - 7
What in vivo imaging methods can be developed to determine and record the identity, quantity, and location of each of the different cell types that contribute to the heterogeneity of a tumor and its microenvironment?
PQ - 11
What mechanisms of action of standard-of-care cytotoxic, radiologic, or targeted therapies affect the efficacy of immunotherapy?