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Visit Case Western Reserve University's uniquely urban campus, located in the heart of Cleveland's cultural hub, University Circle. Plan your trip:

W. David Sedwick, Ph.D.


Professor
Department of Medicine

wds@case.edu
Wolstein Research Building 3-131
(216) 844-7526


Biography

Research

Mutational specificity at DNA sequence level, DNA damage and drug access, DNA repair, genetic susceptibility to cancer, colon cancer, mutagens and their specificity.

Publications

Radivoyevitch T, Loparo KA, Jackson RC, Sedwick WD. On systems and control approaches to therapeutic gain. BMC Cancer. 2006 Apr 25;6:104.

Meyers M, Hwang A, Wagner MW, Bruening AJ, Veigl ML, Sedwick WD, Boothman DA. A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage. Oncogene. 2003 Oct 20;22(47):7376-88. Review.

Yan T, Schupp JE, Hwang HS, Wagner MW, Berry SE, Strickfaden S, Veigl ML, Sedwick WD, Boothman DA, Kinsella TJ. Loss of DNA mismatch repair imparts defective cdc2 signaling and G(2) arrest responses without altering survival after ionizing radiation. Cancer Res. 2001 Nov 15;61(22):8290-7.

Sedwick WD, Markowitz SD, Veigl ML. Mismatch repair and drug responses in cancer. Drug Resist Updat. 1999 Oct;2(5):295-306.

Additional Publications