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case western reserve university

Center for Translational Neuroscience

 

MARK S. SCHER, M.D.


Research Summary


My particular area of interest in pediatric neurointensive care has focused on the fetal and newborn patient with respect to clinical problems presenting in the neonatal intensive care unit which may have initiated during fetal life. The biologic markers to assess healthy and medically-ill neonates have consisted of neurophysiological assessments using EEG-sleep analyses. A number of databases support our program in fetal and neonatal neurology, dealing with both computational neuroscience, and specifically analyses of automated EEG-sleep recordings for sleep state or neonatal seizure detection. Multiple federally funded research grants and awards have been secured over the last 16 years, providing a rich repository of information to study the functional expression of brain organization and maturation sometimes altered by stress or disease states.

Collaborations across disciplines including computer engineering, nursing, neuroimaging, and psychology have resulted in a variety of research endeavors studying neural plasticity as it relates to the experience of prematurity as well as fetal/neonatal brain disorders.