Selected Publications:

Hua, Q. X., Nakagawa, S. H., Wilken, J., Ramos, R. R., Jia, W., Bass, J., and Weiss, M. A. (2003)
A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor.
Genes & Development 17: in press.

Qiao, Z. S., Min, C. Y., Hua, Q. X., Weiss, M. A., and Feng, Y. M. (2003)
In vitro refolding of human proinsulin: Kinetic intermediates, putative disulfide-forming pathway, folding initiation site and potential role of C-peptide in folding process.
J. Biol. Chem., in press.

Hua, Qing-Xin; Jia, Wenhua; Frank, Bruce H.; Phillips, Nelson F. B.; Weiss, Michael A.
A Protein Caught in a Kinetic Trap: Structures and Stabilities of Insulin Disulfide Isomers.
Biochemistry 2002 (41), 14700-14715

Narendra, U., Zhu, L., Li, B., Wilken, J., and Weiss, M. A. (2002)
Sex-specific gene regulation: the Doublesex DM motif is a bipartite DNA-binding domain.
J Biol Chem. 2002 Nov 8;277(45):43463-73

Hua, Q. X., Chu, Y.-C., Jia, W., Phillips, N. F., Wang, R.-Y., Katsoyannis, P. G., and Weiss, M. A. (2002)
Mechanism of insulin chain combination. Asymmetric roles of A-chain a-helices in disulfide pairing.
J Biol Chem. 2002 Nov 8;277(45):43443-53

Lachenman, M., Ladbury, J. E., Phillips, N. B., Narayana, N., Qian, X., Weiss, M. A. (2002)
The hidden thermodynamics of a zinc finger.
J. Mol. Biol. 316: 969-984.
    Appendix: Lachenmann, M., Stern, A. S., and Weiss, M. A. (2002)
    Visualization of 1H-NMR ring currents in a zinc finger.
     J. Mol. Biol.316: 984-989.

Xu, B., Hua, Q. X., Nakagawa, S. H., Jia, W., Chu, Y.-C., Katsoyannis, P. G., and Weiss, M. A. (2002)
Chiral Mutagenesis of Insulin's Hidden Receptor-Binding Surface: Structure of an Allo-isoleucine^A2 Analogue.
J. Mol. Biol. 316: 435-441.

Weiss, M. A., Nakagawa, S. H., Jia, W., Xu, B., Hua, Q. X., Chu, Y.-C., Wang, R. Y., and Katsoyannis, P. G.
Protein Structure and the Spandresl of San Marco: Insulin’s Receptor-Binding Surface Is Buttressed by an Invariant Leucine Essential for Its Stability
Biochemistry, (2002) 41(3): 809-819.

Bin Xu, Qing-xin Hua, Satoe H. Nakagawa, Wenhua Jia, Ying-Chi Chu, Panayotis G. Katsoyannis, and Michael A. Weiss.
A Cavity-Forming Mutation in Insulin Induces Segmental Unfolding of a Surrounding a-Helix.
Protein Sci. 2002 Jan;11(1):104-116

Weiss, M. A., Wan, Z., Zhao, M., Chu, Y.-C., Nakagawa, S. H., Burke, G. T., Jia, W., Helmich, R., Katsoyannis, P. G.
Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J. Mol. Biol. (2002) 315(2): 103-111

Biaoru Li, Wei Zhang, Ging Chan, Agnes Jancso-Radek, Shuhe Liu, and Michael A. Weiss.
Human Sex Reversal Due to Impaired Nuclear Localization of SRY: a Clinical Correlation.
J. Biol. Chem. (2001) 276: 46480-46484

Qing-Xin Hua, Satoe H. Nakagawa, Wenhua Jia, Shi-Quan Hu, Ying-Chi Chu, Panayotis G. Katsoyannis, and Michael A. Weiss.
Hierarchical Protein Folding: Asymmetric Unfolding of an Insulin Analogue Lacking the A7-B7 Inter-Chain Disulfide Bridge.
Biochemistry (2001), 40, 12299-12311

Michael A. Weiss, Qing-Xin Hua, Wenhua Jia, Satoe H. Nakagawa, Ying-Chi Chu, Shi-Quan Hu, and Panayotis G. Katsoyannis.
Activities of Monomeric Insulin Analogs at Position A8 are Uncorrelated with their Thermodynamic Stabilities.
J. Biol. Chem. (2001) 276: 40018-40024

Dong J, Wan ZL, Chu YC, Nakagawa SN, Katsoyannis PG, Weiss MA, Carey PR.
Isotope-Edited Raman Spectroscopy of Proteins: a General Strategy to Probe Individual Peptide Bonds with Application to
Insulin. J Am Chem Soc. (2001) Aug 15;123(32):7919-7920, PMID: 11493071

Narendra Narayana, Qing-xin Hua, and Michael A. Weiss.
The dimerization domain of HNF-1a: structure and plasticity of an intertwined four-helix bundle with application to diabetes mellitus.
J. Mol. Biol. (2001) July; 310(3):635-658

Weiss, M. A.,
"Floppy SOX: Mutual Induced Fit in HMG (High-Mobility Group) Box-DNA Recognition"
Molecular Endocrinology (2001) 15(3): 353-362

Ukiyama, E., Jancso-Radek, A., Li, B., Milos, L., Zhang, W., Phillips, N.B., Norikawa, N., King, C., Chan, G., Haqq, C. M., Radek, J.T., Poulat, F., Donahoe, P.K. and Weiss, M.A.,
"SRY amd Architectural Gene Regulation: The kinetic Stability of a Bent Protein-DNA COmplex Can Regulate Its Transcriptional Potency"
Molecular Endocrinology (2001) 15:363-377

Hua, Q. X., Dementieva, I. S., Walsh, M. A., Hallenga, K., Weiss, M. A., and Joachimiak, A.
"A Thermophilic Mini-chaperonin Contains a Conserved Polypeptide-binding Surface: Combined Crystallographic and NMR Studies of the GroEL Apical Domain with Implications for Substrate Interactions"
J. Mol. Biol. (2001) 306:513-525.

Zhu, L., Wilken, J., Phillips, N.B., Narendra, U., Chan, G., Stratton S.M., Kent, S.B., and Weiss, M. A.,
"Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers"
Genes & Development (2000) 14:1750-1764

Weiss, M. A., Hua, Q. X., Jia, W., Chu, Y. C., Wang, R.Y., and Katsoyannis, P.G.
"Hierarchical Protein 'Un Design': Insulin's Intrachain Disulfide Bridge Tethers a Recognition Alpha-Helix"
Biochemistry (2000), 39:15429-15440

Hua, Q. X., Zhao, M., Narayana, N., Nakagawa, S. H., Jia, W., and Weiss, M. A.,
"Diabetes-associatedMutations in a b-Cell Transcription Factor Destabilize an Anti-Parallel "Mini-Zipper."
Proc. Natl. Acad. Sci. USA (2000) 97:1999-2004.
Abstract available

Benevides, J. M., Li, T., Lu, X. J., Srinivasan, A.R., Olson, W. K., Weiss, M. A., and Thomas Jr., G. J.,
"Protein-Directed DNA Structure II. Raman Spectroscopy of a Leucine Zipper bZIP Complex"
Biochemistry (2000) 39:548-556.

Benevides, J. M., Chan, G., Lu, X. J., Olson, W. K., Weiss, M. A., and Thomas Jr., G. J.,
"Protein-Directed DNA Structure. I. Raman Spectroscopy of a High-Mobility-Group Box with Application to Human Sex Reversal."
Biochemistry (2000) 39:537-547.

Weiss, M. A. and Narayana, N.,
"RNA Recognition by Arginine-Rich Peptide Motifs."
Biopolymers (1999) 48:167-180.

Wang, B., Jones, D. N. M., Kaine, B. P., and Weiss, M. A.,
"High-Resolution Structure of an Archaeal Zinc Ribbon Defines a General Architectural Motif in Eukaryotic RNA Polymerases."
Structure (1998) 6:555-569.

Su, L., Radek, J. R., Labeots, L. A., Hermanto, P., Chen, H., Nakagawa, S., Zhao, M., Kates, S., Hallenga, K., Chan, G., Weiss, M. A.,
"An RNA Enhancer in a Phage Transcriptional Antitermination Complex Functions as a Structural Switch."
Genes & Development (1997) 11:2214-2226.

Labeots, L., and Weiss, M. A.,
"Electrostatics and Hydration at the Homeodomain-DNA Interface: Chemical Probes of an Interfacial Water Cavity."
J. Molec. Biol. (1997) 269:113-128.

Jacoby, E., Hua, Q. X., Stern, A., Frank, B. H., and Weiss, M. A.,
"Structure and Dynamics of a Protein Assembly: 1H-NMR Studies of the 36 kD R6 Insulin Hexamer."
J. Molec. Biol. (1996) 258:136-157.

Hua, Q. X., Gozani, S., Chance, R. E., Hoffmann, J. A., Frank, B. H., and Weiss, M. A.,
"Structure of a Protein in a Kinetic Trap."
Nature Struct. Biol. (1995) 2:129-138.

Haqq, C. M., King, C.-Y., Ukiyama, E., Haqq, T. N., Falsalfi, S., Donahoe, P. K., and Weiss, M. A.,
"Molecular Basis of Mammalian Sexual Determination: Activation of MIS by SRY."
Science (1994) 266:1494-1500.

King, C. Y. and Weiss, M. A.,
"The SRY HMG-Box Recognizes DNA by Partial Intercalation in the Minor Groove: a Topological Mechanism of Sequence Specificity."
Proc. Natl. Acad. Sci. U.S.A. (1993) 90:11990-11994.

Qian, X., Jeon, H., Agarwal, K., and Weiss, M. A.,
"The Zn Ribbon: Structure of the Nucleic-Acid Binding Domain of Elongation Factor TFIIS."
Nature (1993) 365:277-279.

Hua, Q. X., Shoelson, S. E., Kochoyan, M., and Weiss, M. A.,
"Receptor Binding Redefined by a Structural Switch in the Solution Structure of a Mutant Human Insulin."
Nature (1991) 354:238-241.

Weiss, M. A., Ellenberger, T. E., Wobbe, C. R., Harrison, S. C., and Struhl, K.,
"Folding Transition in the DNA-Binding Domain of GCN4 on Specific DNA Binding to DNA."
Nature (1990) 347:575-578.