University Hospitals Case Medical Center
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Research in Emergency Medicine

Johnathan Sheele MD, MPH, MHS

Johnathan Sheele

Associate Fellowship
Director, International
Emergency Medicine,
University Hospitals
Case Medical Center

Assistant Professor,
Case Western
Reserve University

UH/CMC offers magnificent research opportunities! The faculty and resources of a major medical school, the Wolstein Research Building, the UH Office of Grants and Research Compliance, 3 on-site IRBs and many more resources are available to the researcher who is interested in sponsored studies, interdepartmental collaboration and more. For a comprehensive list of faculty and resident research, please read below.

Departmental efforts have focused on HIV testing and stroke identification to date. Asthma, suicide, and physician well-being are areas of faculty research interest. Emergency Medicine Residents have regular research seminars in all three years, culminating in a publishable project. Extensive resources for research are available including University Hospitals, Case Western Reserve University, as well as the Global Health Center to name a few. Collaboration with each other and with the Emergency Medicine Research Division's (EMRD) Research Assistants and Associates is encouraged. Emergency Medicine Residents will have yearly opportunities to present their ongoing efforts at one or another of the local research showcases.

All residents have access to the EMRD, a group of undergraduate and graduate student researchers who assist the emergency medicine residents in data collection, statistical analysis and manuscript preparation. By the time of graduation, all residents are expected to have a publication worthy of a peer-reviewed journal and will have presented at a local, regional or national meeting. The Emergency Medicine Research Division (EMRD) meetings occur weekly on Thursday evenings and all prospective residents and interviewees are invited to attend. Please contact Dr. Totten for more information on time and location.

Emergency Medicine Research Division (EMRD)

To contact Dr. Sheele email him at:

UHCMC Department of EM Research Updates

Resident Research & Publications

Charbonneau HM, Bruxvoort KJ, Giambernardi TA, Goolsby JC, Qian CN, Zylstra CR, Robinson DR, Roy-Burman P, Shaw AK, Buckner-Berghuis BD, Sigler RE, Resau JH, Sullivan R, Bushman W, Willams BO. Inactivation of APC in the Mouse Prostate Causes Prostate Carcinoma. Cancer Research. 2007 Mar; 67(6): 2490-2496. Cited in PubMed; PMID: 17363566.

Charbonneau HM, Giambernardi TA (2004, September). Inactivation of APC in the Mouse Prostate Causes Prostate Carcinoma. Poster presented at: Annual Wnt Meeting; Ann Arbor, MI.

Charbonneau HM, Giambernardi TA. (2005, May). Inactivation of APC in the Mouse Prostate Causes Prostate Cancer. Poster presented at: Van Andel Research Institute Annual Scientific Retreat; Rothbury, MI.

Charbonneau, HM. (2004, April). Developing a Mouse Model for Prostate Cancer. Poster presented at: Posters on the Hill; DC, DC.

Desai P. "Respiratory Side Effects of Adalimumab: A Success Story." Poster Presentation at Baltimore Convention Center. Published in Proceeds of Society of Teachers of Family Medicine. October 31, 2008

Desai P. "Laproscopic Management of Primary Ovarian Ectopic Pregnancy." Case Presentation. Wyckoff Heights Medical Center, Brooklyn NY. May 22 2008.

Gilbert JG, Newman AH, Gardner EL, Ashby CR, Heidbreder CA, Pak AC, Peng XQ, Xi ZX.. Acute administration of SB-277011-A, NGB 2904, or BP 897 Inhibits Cocaine Cue-Induced Reinstatement of Drug-Seeking Behavior in Rats: Role of Dopamine D3 Receptors.. Synapse. 2005 Mar; 2005(57): 17-28.

Pak AC, Ashby CR, Heidbreder CA, Pilla M, Gilbert JG, Xi ZX, Gardner EL.. The Selective Dopamine D3 Antagonist SB-277011-A Reduces Nicotine-Enhanced Brain Reward and Nicotine-Paired Environmental Cue Functions.. International Journal of Neuropsychopharmacology.. 2006 Apr; 9(1): 585-602.

Peng XQ, Li X, Gilbert JG, Pak AC, Ashby CR, Brodie JD, Dewey SL, Gardner EL, Xi ZX.. Gamma-Vinyl GABA Inhibits Cocaine-Triggered Reinstatement of Drug-Seeking Behavior in Rats by a Non-Dopaminergic Mechanism.. Alcohol and Drug Dependence. 2008 Mar; 97(1): 216-225.

XI ZX, Gilbert JG, Pak AC, Ashby CR, Heidbreder CA, Gardner EL.. Selective Dopamine D3 Antagonism by SB-277011-A Attenuates Cocaine Reinforcement as Assessed by Progressive-Ratio Variable-Cost Variable-Payoff Fixed-Ratio Cocaine Self-Administration in Rats.. Journal of Neuroscience. 2005 Jan; 21(1): 3427-3438.

XI ZX, Gilbert JG, Peng XQ, Pak AC, Li X, Gardner EL.. Cannabinoid CB-1 Receptor Antagonist AM 251 Inhibits Cocaine-Primed Relapse in Rats: Role of Glutamate in the Nucleus Accumbens.. Journal of Neuroscience. 2006 Aug; 26(33): 8531-8536.

Xi ZX, Newman AH, Gilbert JG, Pak AC, Peng XQ, Ashby CR, Gitajn L, Gardner EL.. The Novel Dopamine D3 Receptor Antagonist NGB 2904 Inhibits Cocaine's Rewarding Effects and Cocaine-Induced Reinstatement of Drug-Seeking Behavior in Rats.. Neuropsychopharmacology. 2006 May; 31(1): 1393-1405.

Xi ZX, Spiller K, Pak AC, Gilbert JG, Dillon C, Li X, Peng XQ, Gardner EL.. Cannabinoid CB1 Receptor Antagonists Attenuate Cocaine's Rewarding Effects: Experiments with Self-Administration and Brain-Stimulation Reward in Rats.. Neuropsychopharmacology. 2008 May; 33(1): 1735-1745.

Zheng-Xiong Xi, Gilbert JG, Campos AC, Kline N, Ashby CR, Hagan JJ, Heidbreder CA, Gardner EL.. Blockade of Mesolimbic Dopamine D3 Receptors Inhibits Reinstatement of Cocaine-Seeking in Rats.. Psychopharmacology. 2004 Apr; 2004(176): 57-65.

Rose SH, Linsenbigler SW, Waintrub M, Karimova N, (2007) USMLE II CS Rocky Mountain Rapid Review, Denver CO, Maval Publishing Inc.

Rose SH, Saxena K. The effects of Vitamin C and Alcohol on Sister Chromatid Exchanges in human Lymphocytes in Vivo. Proceedings of the Louisiana Academy of Sciences, March 1992

Rose SH, Saxena K. The effects of alcohol consumption on Sister Chromatid Exchanges in Human lymphocytes in Vivo. Proceedings of the Louisiana Academy of Sciences, March 1993

Rose SH, Minter SY, Bustos LD, Chrissman H. High Concentrations of Staurosporin Causes Prolonged G1 arrest in Normal Cells. Annual meeting of the Cell Kinetics Society, Santa Fe, New Mexico, March 9-12, 1995

Nanci GN, Collier MJ. Rose SH. Twenty Years of Dysuria in a Patient with Addison's Disease. Cases Journal. 2010

Handa H, Hegde UP, Kotelnikov V, Mundle S. Dong LM, Burke P. Rose S, Gaskin F, Raza A, Preisler HD: Bcl-2 and c-myc expression, cell cycle kinetics and Apoptosis during the progression of Chronic Myelogenous Leukemia from Diagnosis to Blastic Phase. Leuk Res., 21: 479-489, 1997

Handa H, Hegde UP, Kotelnikov V, Mundle S. Dong LM, Burke P. Rose SH, Hsu WT, Gaskin F, Raza A, Preisler HD: The effects of 13-cis Retinoic Acid and Interferon-a in Chronic Myelogenous leukemia in Vivo in Patients. Leuk Res., 21 (11/12): 1087-1096, 1997

Mundle SD, Venugopal P, Shetty V, Ali A, Handa H, Rose SH, Chopra H, Gregory SA, Preisler HD, Raza A,: The relative extent in propensity of CD34+ vs CD34- cells to undergo Apoptosis in Myelodysplastic Marrow. Int. J. Hematol, 69: 152-159, 1999

Handa H, Rose SH, Chopra H, Gao X, Bi S, Preisler HD. Studies of Cyclin E, D1, IRF-1, and IRF-2 genes in standard and poor prognosis Acute Myelogenous Leukemia. Blood 88 (10): 156b Abstr # 3351, 1996

Gao XZ, Handa H, Bi S, Kotelnikov V, Rose SH, Preisler HD. Chronic Myelogenous Leukemias Associated with B3A2 and B2A2 BCR/ABL mRNAs are biologically different. Blood 88 (10) 573a Abstr # 2282, 1996

Mundle SD, Venugopal P, Shetty V, Ali A, Handa H, Rose SH, Chopra H, Gregory SA, Preisler HD, Raza A: Contrasting Incidence of Apoptosis in CD34+ vs CD34- cells in Myelodysplastic syndrome (MDS). Blood 90 (10): 582a Abstr # 2588, 1997.

Yax JA., Brenner BE. Suicide and Homicide Risk Related to Household Firearm Ownership and Manner of Storage. SAEM 2010, Phoenix AZ

Yax JA, Smith A, "New Advances in Scapholunate Advance Collapse Treatment" Mayo Clinic Upper Extremities Conference, Phoenix, April 19, 2000.

Yax JA, Tacholpulou O, Anthony K, Hall GS, "Case Presentation: First case of Clostridium innocuum as etiology of infection in prosthetic joint", "Advance for Medical Laboratory Professionals" September 4, 2001.

Yax JA, Torres WA, Moncayo R, Gunaratnam N, Robinson E, Moya M, Calvert B, Reed B,. "Survey of Health Nutrition and Recurrent Infectious Diseases among three Shuar Villages in the Ecuadorian Amazon" IDSA Poster Presentation San Diego October, 2003, American Society of Tropical Medicine and Hygiene (ASTMH) meeting, December 2003.

Yax JA, Torres WA, Starr-Riviera C, Engleberg CE, [Epidemiología Molecular de la Malaria en la Amazonia], "Molecular Epidemiology of Plasmodium falciparum in the Ecuadorian Amazon Rainforest" Presented at the "Primer Congreso Médico de Acualización en la Amazonía"on July 26, 2006, Puyo, Ecuador.

Yax JA, Collins C, Malani P, Malaria Prophylaxis in the Elderly Traveler. Clinical Geriatrics, 2007; 15(8) 36-45.

Department of Emergency Medicine Residency Program
University Hospitals Case Medical Center
11100 Euclid Avenue, Cleveland, OH 44106
Phone: 216-844-3610 Fax: 216-844-7783