| Multiple Lacunar State: Flair axial MRIs. Note the numerous infarcts in the deep white matter bilaterally. A similar MRI picture could be seen in advanced multiple sclerosis or an inherited disorder of white matter (i.e., leukodystrophy). This multi-lacunar state (a.k.a., Binswanger's disease) often results in a subcortical dementia. In this condition, patients develop memory loss, altered mood, and cognition dysfunction, often along with focal motor and sensory changes. Patients usually have chronic hypertension and/or diabetes. Other prominent features of the disease include urinary incontinence, a slow unstable gait, tremors, clumsiness, behavioral and personality changes, lack of facial expression, and speech difficulties. |
Revised
11/23/06
Copyrighted 2006. David C Preston