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Case 11 - Pilocytic Astrocytoma

A 17 year-old man presented with a headache and gait instability.

Show the Large Cystic Cavity          Note the Enlarged Temporal Horns          Note the Compression of the Pons

Pilocytic Astrocytoma. (Left) T2-weighted axial MRI; (Right) T1-weighted axial MRI. Note the large cystic mass in the region of the fourth ventricle and vermis of the cerebellum. Also note the marked compression of the adjacent brainstem. Surgical resection demonstrated the lesion to be a pilocytic astrocytoma.

The World Health Organization scheme for grading gliomas from benign to progressively more malignant is as follows:

● Grade I - Pilocytic
● Grade II - Low-grade
● Grade III - Anaplastic
● Grade IV - Glioblastoma multiforme

Note that pilocytic tumors are very benign histologically. They are the most common astrocytic tumors in children and most often are located in the cerebellum. On imaging, they are cystic, often with an enhancing tumor nodule. Because they most often occur in the cerebellum, initial symptoms tend to be headache and gait ataxia. Non-communicating hydrocephalus can occur. These lesions are typically treated by surgical resection and have an excellent prognosis.


Revised 11/27/06.
Copyrighted 2006. David C Preston