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Pontine and Midbrain Infarction - Case 2

A 68 year-old woman was admitted with complaints of nausea, vomiting and right sided weakness. Within four hours, she was quadriplegic and could not speak. However, she could look up on command. An emergency angiogram demonstrated complete occlusion of the basilar artery.

Show the Area of the Infarction

Pontine and Midbrain Infarction: Axial CT scans at the level of the pons (left) and upper pons/midbrain (right) at day 3. Note the dark signal within the base of the pons and lower midbrain. If one looks closely, one can see that the tegmentum, which is immediately ventral to the fourth ventricle, is not affected. By day 3, the infarct is now well seen on the CT scan.

Occlusion of the basilar artery may result in a "locked-in" syndrome, wherein the patient is completely quadriplegic and unable to speak. Infarction of the base of the pons interrupts the bilateral corticobulbar and corticospinal tracts, leaving the patient essentially disconnected from their body. Although such patients may be mistaken for being in a coma, they are actually awake and alert as the tegmentum is spared, the region where the ascending reticular activating system is located. Because control of vertical eye movements is located in the rostral midbrain, often the only voluntary movement is vertical gaze.


Revised 11/23/06
Copyrighted 2006. David C Preston