A 4 year-old girl presented with seizures and a delay in motor milestones.

TS is a multisystemic genetic disorder with prominent CNS manifestations. Only a subset of patients display the classic triad of intractable seizures, mental retardation, and dermal angiofibromas. Several abnormalities may be present on brain imaging, including cortical tubers (hamartomas), bilateral and multiple subependymal nodules, and subependymal giant-cell astrocytomas that are most frequently found at the foramen of Monro.