|
A 5 year-old boy presented with seizures and mild developmental delay. |
| Tuberous Sclerosis (TS):
T1-weighted with gadolinium axial MRIs. Note the numerous small enhancing lesions, most
of which are subependymal near the ventricles. This is the typical appearance of
tuberous sclerosis.
TS is a multisystemic genetic disorder with prominent CNS manifestations. Only a subset of patients display the classic triad of intractable seizures, mental retardation, and dermal angiofibromas. Several abnormalities may be present on brain imaging, including cortical tubers (hamartomas), bilateral and multiple subependymal nodules, and subependymal giant-cell astrocytomas that are most frequently found at the foramen of Monro. |
Revised
11/29/06
Copyrighted 2006. David C Preston