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Collage of fluorescence and brightfield images from users of the core.

The School of Medicine Light Microscopy Core Facility on the Case Western Reserve University campus is a shared resource that offers a wide range of imaging services to the research community. Our facilities are committed to enhancing and expanding collaborative capabilities of research in northern Ohio. Our core directors and lab personnel are highly trained experts in their field who provide technical expertise, consultation, and training. The core is conveniently located in two locations: the Main Light Microscopy Imaging Suite located on the 6th floor of the Robbins Building and the Two-photon Imaging Suite located on the 5th floor of the Wood Research Tower.

In addition to providing the necessary training for users to independently operate core instruments, staff is available to conduct imaging experiments as well, on a fee-for-service basis. Imaging techniques available through the cores include:

  • confocal 
  • super-resolution 
  • multi-photon
  • standard transmitted light
    • brightfield
    • darkfield
    • phase contrast
    • differential interference contrast
    • polarization
    • fluorescence
  • slide scanning (brightfield and fluorescence)
  • TIRF

Our range of instruments allows for most types of modern imaging techniques from basic widefield imaging to very high spatial and temporal resolution imaging of fixed and live cells, tissues or small organisms.

Image processing and analysis capabilities include:

  • quantification
  • co-localization analysis
  • deconvolution
  • 3D reconstruction
  • stereology


Arrange a tour or presentation for your group today!