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School of
Medicine

Neurosciences

Xiong, Wen-Cheng

Xiong, Wen-Cheng

‌Wen-Cheng Xiong, PhD‌‌

Riuko and Archie G. Co Professor and Professor (with tenure)

Education

PhD, John Hopkins University, 1994

Research Interests

We are interested in molecular mechanisms underlying neural development, neuro-degeneration, and bone homeostasis. Although neural development, neurodegeneration, and bone homeostasis are three distinct events/processes, there are potential links among these processes. For examples, patients with neurodegenerative disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), frequently have non-cognitive/non-motor related defects. These non-typical symptoms occur earlier in AD/PD patients’ life, thus, they not only impact patients’ quality of life, but also could be predictor for disease progression. We have found that one of these non-typical defects is bone-degenerative-like phenotype. We therefore have invested significant efforts in understanding why and how the non-typical deficits (e.g., bone deficits) are associated with AD/PD. Technically, we have used a combination of biochemical (in vitro), cell biological (in culture), and genetic mutant animal models to address this issue.