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School of
Medicine

Faculty

Warren R. Selman, M.D.

Warren R. Selman, M.D.

Harvey Huntington Brown Jr., Professor and Chairman; Neurosurgeon-in-Chief, University Hospitals Cleveland Medical Center; Case Western Reserve School of Medicine

 
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Medical School Education

University of Toledo
Bachelor of Science, Summa cum Laude, 1970 – 1973

Case Western Reserve University School of Medicine
Doctor of Medicine, 1973 – 1977

Graduate Medical Education

University Hospitals Cleveland Medical Center
Surgical Intern, 1977 – 1978

University Hospitals Cleveland Medical Center
Research Fellow, 1978 – 1980

University Hospitals Cleveland Medical Center
Neurosurgical Resident, 1980 – 1984

The Mayo Clinic - Rochester, MN
Neurosurgical Fellow, 1984

Clinical Interests

Cerebrovascular Surgery, Skull Base Surgery

Rothstein BD, Selman WR. Evaluating Simulation as a Teaching Tool in Neurosurgery. Virtual Mentor. 2015; 17:33-36. http://virtualmentor.ama-assn.org/2015/01/medu1-1501.html.

Arafah, B, Gabriek Z, Selman W, Shasby, G. Pitfalls in the Diagnosis and Management of Cushing’s Syndrome. NeuroFocus Journal: Neurosurgical Focus Podcast. February 2015.

Bansal V, El Asmar N, Selman WR, Arafah BM. Pitfalls in the diagnosis and management of Cushing's syndrome. Neurosurg Focus. 2015 Feb;38(2):E4. doi: 10.3171/2014.11.FOCUS14704. Review.

Wright J, Wright CH, Selman WR. Management of Cushing's disease in the US. Neurosurg Focus. 2015 Feb;38(2):E3. doi: 10.3171/2014.11.FOCUS14771.

Zada G, Carmichael JD, Selman WR. Introduction: Cushing's disease: a century of evolving diagnostics and therapeutics for an often elusive entity. Neurosurg Focus. 2015 Feb;38(2):E1. doi: 10.3171/2014.11.FOCUS14788.

Carmichael JD, Zada G, Selman WR. Making the diagnosis of cyclic Cushing's syndrome: a position statement from the topic editors. Neurosurg Focus. 2015 Feb;38(2):E8. doi: 10.3171/2014.11.FOCUS14778.

Bonda DJ, Manjila S, Selman WR, Dean D. The recent revolution in the design and manufacture of cranial implants: modern advancements and future directions. Neurosurgery. 2015 Nov;77(5):814-824.

Nahabet EH, Gatherwright J, Vockley J, Henderson N, Tomei KL, Grigorian AP, Kaminski B, Bass N, Selman WR, Lakin GE. Postnatal Pancraniosynostosis in a Patient With Infantile Hypophosphatasia. Cleft Palate Craniofac J. 2015 Jul 14. [Epub ahead of print]

Seicean A, Alan N, Seicean S, Neuhauser D, Selman WR, Bambakidis NC. Risks associated with preoperative anemia and perioperative blood transfusion in open surgery for intracranial aneurysms. J Neurosurg. 2015 Jul;123(1):91-100. doi: 10.3171/2014.10.JNS14551. Epub 2015 Apr 10.

Abboud SE, Wolansky LJ, Manjila SV, Lo SS, Arafah BM, Selman WR, Couce ME, Rogers LR. Histologically Proven Radiation-Induced Brainstem Glioma 93 Months After External Beam Radiotherapy for Pituitary Macroadenoma: Radiation Treatment Dose and Volume Correlation. J Neuroimaging. 2015 Jul-Aug;25(4):674-6. doi: 10.1111/jon.12181. Epub 2014 Oct 27. 

 

 

 

 

 

Selman WR, Tarr RW, Sunshine JL, Tarr RW, Ratcheson RA.  Arteriovenous malformations, In: Neurology in Clinical Practice: Principles of Diagnosis and Management, 4th Edition, Volume II, Bradley WG, Daroff RB, Fenichel GM, Jankovic J (Eds).  Butterworth-Heinemann, Woburn, Massachusetts, pp. 1285-1297; 2004.

Bambakidis NC and Selman WR.  Subarachnoid hemorrhage, In: Current Clinical Neurology: Critical Care Neurology and Neurosurgery, Suarez J (Ed).  Humana Press, Inc., Totowa, New Jersey, pp. 365-377; 2004.

Rodrigue T, Selman  WR.  Postoperative management in the neurosciences critical care unit, In: Current Clinical Neurology: Critical Care Neurology and Neurosurgery, Suarez J (Ed).  The Humana Press, Inc., Totowa, New Jersey, pp. 433-448; 2004.

Selman WR, Hsu D, Tarr RW, Ratcheson RA. Intracranial aneurysms and subarachnoid hemorrhage, In: Neurology in Clinical Practice: Principles of Diagnosis and Management, 5th Edition, Volume II, Bradley WG, Daroff RB, Fenichel GM, Jankovic J (Eds).  Butterworth-Heinemann, Butterworth-Heinemann, Philadelphia, Pennsylvania, pp. 1243-1257, 2007.

Selman WR, Blackham K, Tarr RW, Ratcheson RA.  Arteriovenous malformations, In: Neurology in Clinical Practice: Principles of Diagnosis and Management, 5th Edition, Volume II, Bradley WG, Daroff RB, Fenichel GM, Jankovic J (Eds).  Butterworth-Heinemann, Philadelphia, Pennsylvania, pp. 1259-1271, 2007.

Dashti SR, Miller JP, Tarr, RW, Selman WR.  Vascular lesions of the cerebellopontine angle, In: Surgery of the Cerebellopontine Angle, Bambakidis NC, Megerian CA, Spetzler RF (Eds).  People’s Medical Publishing House, Decker, Inc., Shelton, Connecticut, pp. 287-299, 2009.

Dashti, SR., Sunshine JL, Tarr RW, Selman WR,   Arteriovenous malformations: functional evaluation and diagnosis, In: Intracranial Arteriovenous Malformations, Stieg PE, Batjer HH and Samson DS (Eds).  Quality Medical Publishing, St. Louis, Missouri, pp 115 – 122, 2006.

Hoffer SA, Singer J, Selman WR, Bambakidis NC. Spontaneous intracerebral hemorrhage. In: Ellenbogen RG, Abdulrauf SI, Sekhar LN, eds. Principles of Neurosurgery. 3rd ed. Philadelphia, Penn: Elsevier; 2012: Chapter 16.

Bambakidis NC, Nelson JT, Selman WR. Cerebral protection In: Aminoff MJ, ed. Encyclopedia of the Neurological Sciences.  2nd ed. Philadelphia, Penn: Elsevier Inc.; May, 2014.

Selman WR,  Bambakidis NC, Hdeib A.  Subarachnoid hemorrhage: Critical Care Neurology and Neurosurgery, Current Clinical Neurology. The Humana Press, Inc. 2014.  

Current Support

Co-Investigator at University Hospitals Cleveland Medical Center: Clot Lysis Evaluating Accelerator Resolution of Intraventricular Hemorrhage Phase III (NIH Protocol CLEAR), Johns Hopkins Medical Center/NIH. June, 2010 – June, 2015.

Past Support

Primary Investigator, American Heart Association, Northeast Ohio Affiliate Grant-in-Aid Award, “Metabolic Analysis of Focal Cerebral Ischemia.”  #4480, July 1, 1985 through January 30, 1986.

Primary Investigator, Case Western Reserve University Biomedical Research Support Grant Program, “Metabolic Analysis of Focal Cerebral Ischemia.”  #RR-05410-24, November 1, 1985 through March 31, 1986.

Primary Investigator, Young Clinician Investigator Award, Research Foundation of the Association of Neurological Surgeons, “Metabolic Analysis of Focal Cerebral Ischemia.”  #4480R, January 1, 1987 through December 31, 1987.

Primary Investigator, American Heart Association, Northeast Ohio Affiliate Grant-in-Aid Award, “Metabolic Analysis of Focal Cerebral Ischemia.”  #4480R, January 1, 1987 through December 31, 1987.

Primary Investigator, Case Western Reserve University Research Initiation Grant, “Subarachnoid Hemorrhage—Rat Model.”  May 1, 1987 through April 30, 1988.

Primary Investigator, American Heart Association, Northeast Ohio Affiliate Grant-in-Aid Award, “New Model of Focal Chronic Cerebral Vasospasm after Subarachnoid Hemorrhage in the Rat.”  #4677, July 1, 1989 through June 30, 1990.

Primary Investigator, National Institutes of Health, First Award, “Reversible Focal Cerebral Ischemia.”  #NEUA-1-R29, September 1, 1989 through August 31, 1994.

Primary Investigator at Case Western Reserve University, University Hospitals of Cleveland, The Upjohn Company/University of Virginia, “Efficacy/Safety Study of Tirilizad Mesylate (U-74, 006F) in Patients with Subarachnoid Hemorrhage.”  September 1, 1992 through November 15, 1993.

Primary Investigator at Case Western Reserve University, University Hospitals of Cleveland, National Institutes of Health, “North American Symptomatic Carotid Endarterectomy Trial.”  #RO1 NS24456, September 1, 1992 through August 31, 1997.

Research Mentor to Anthony G. Alastra, Case Western Reserve University, University Hospitals of Cleveland, Howard Hughes Medical Institute, “Pathophysiology of Reversible Focal Ischemia:  Salvaging the Penumbra.”  June 1, 1994 through May 31, 1995.

Primary Investigator at Case Western Reserve University, University Hospitals of Cleveland, McMasters University,  “ASA and Carotid Endarterectomy,” (WM82434).  July 18, 1994 through March 31, 1998.

Co-Investigator, National Institutes of Health, “Focal Stroke:  Metabolism and pH Using Neutral Red.”  #2 RO1 NS22571-04A1, March 1, 1995 through February 28, 1998.

Co-Investigator, American Heart Association, “Mitochondrial Function in Ischemic Injury in Cortical Neurons.”  July 1, 1996 through June 30, 1998.

Primary Investigator, National Institutes of Health, “Alzheimer Proteins during Brain Metabolic Stress.”  #RO1 NS34731, September 30, 1997 through May 31, 2002. 

Co-Investigator at University Hospitals of Cleveland, NINDS, “Hemicraniectomy and Durotomy Upon Deterioration for Massive Hemispheric Infarcts, A Multicenter Prospective Randomized Study (HEADFIRST).”  Pilot Clinical Trial awarded funding from October 1999 through September 2002.

Co-Investigator at University Hospitals of Cleveland, NIH, University of Cincinnati, “Interventional Management of Stroke.”  April 1, 2001 through March 31, 2003.

Co-Investigator at Case Western Reserve University School of Medicine, “Fetal Hypoxia and Nicotine Exposure and Neonatal Dysfunction.”  Philip Morris External Research Program, May 1, 2001 through April 30, 2004.

Principal Investigator at University Hospitals of Cleveland, “Use of a Venous Catheter for Core Cooling and Rewarming for Temperature Control During Aneurysm Surgery (TCAS).” Innercool Therapies, Inc., July 1, 2000 through December 31, 2002.

Co-Investigator at Case Western Reserve University School of Medicine and University Hospitals of Cleveland, “Subarachnoid Hemorrhage – Mortality and Management Before and After Published Guidelines.”  American Heart Association Research Award, July 1, 2002 thru June 30, 2003.

Co-Investigator at University Hospitals of Cleveland, “A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Effects of a Targeted Concentration of Repinotan in Patients with Acute Ischemic Stroke.”  Bayer Corporation, December 1, 2001 through November 30, 2005. 

Co-Principal Investigator at University Hospitals of Cleveland, “An Open-Label, Randomized, Parallel Group Study to Confirm the Safety and Efficacy of PROCRIT® (Epoetin Alfa) Administered Perioperatively vs. the Standard of Care in Blood Conservation in Subjects Undergoing Major Elective Spinal Surgery (Protocol #PR97-19-002)”.  OrthoBiotech Corporation, September 1, 2003 through August 31, 2005. 

Clinical Consultant for Cleveland Medical Devices, Inc., “Untethered Home Therapy System” (Grant #1-R43-NS046976-01A1), NIH/NINDS, August 15, 2004 through August 15, 2005.

Principal Investigator at Case Western Reserve University School of Medicine and University Hospitals Case Medical Center: Carotid Occlusion Surgery Study - NS 42167 (COSS).  National Institutes of Health, Washington University, July 1, 2001 - 2010.

Co-Investigator at University Hospitals Case Medical Center: The Cancer Genome Atlas (TCGA). SAIC Frederick Inc/National Cancer Institute, 2008 – 2010.

Co-investigator at University Hospitals Case Medical Center: Double-blind, randomized, placebo-controlled study to assess efficacy and safety of clazosentan to reduce vasospasm-related and all-cause mortality in adult patients with aneurysmal subarachnoid hemorrhage treated by surgical clipping (Conscious-2), Actelion.  2009 – 2010.

Co-Investigator at University Hospitals Case Medical Center: Interventional Management of Stroke III (IMSIII).  University of Cincinnati/National Institutes of Health, 2006 – 2010.

Co-Investigator at University Hospitals Case Medical Center: Intraoperative Stereotactic CT-guided Endoscopic Surgery – ICES (NIH/NINDS Protocol MISTIES-ICES).  Johns Hopkins Medical Center/NIH.  June, 2009- 2011.

Principal Investigator at University Hospitals Case Medical Center: Study of Neuroprotective and Neurogenerative Effects of Amphetamine or Methamphetamine/CART from the NIH/NIDA, March, 2010 – February, 2012. ($72,000.00)

Site PI at University Hospitals Case Medical Center:  Carotid Occlusion Surgery Study (COSS). University of North Carolina/National Institutes of Health (NINDS), December, 2007 - November, 2012. ($20,150.00)

Co-Investigator at University Hospitals Case Medical Center: Biomarker & Phase II study of GDC-0449 for recurrent GBM. ARRA ACTNOW/National Institutes of Health, 2010 – 2013.

Internal Advisory Board Member at University Hospitals Case Medical Center: Ohio Brain Tumor SPORE. National Institutes of Health, 2015.