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Medicine

Reproductive Biology

NRG Oncology Group

NRG Oncology Group

NRG Oncology brings together the unique and complementary research areas of the National Surgical Adjuvant Breast and Bowel Project (NSABP), the Radiation Therapy Oncology Group (RTOG) and the Gynecologic Oncology Group (GOG). NRG Oncology builds upon our more than 150 years of cumulative research experience to conduct practice defining, multi-institutional clinical trials resulting in the improved survival and quality of life of patients with cancer.

Several members of the department hold leadership positions, including Dr. Waggoner who is a member of several committees, and Nancy Fusco, RN who is Chairperson of the Protocol Working Group Mentorship Committee.

Clinical Trials

Endometrial Recurrent or Persistent
GOG 0229O A Randomized Phase II Study With a Safety Lead-In to Assess the Antitumor Efficacy of the MEK Inhibitor Trametinib Alone or in Combination with GSK 241795, an AKT Inhibitor, in Patients with Recurrent or Persistent Endometrial Cancer
Uterine Corpus
GOG 0238 A Randomized Trial of Pelvic Irradiation with or without Concurrent Weekly Cisplatin in Patients with Pelvic-Only Recurrence of Carcinoma of the Uterine Corpus
Ovary, Peritoneal, Recurrent/Persistent
GOG 0170R A Phase II Evaluation of Dalantercept (NSC #757172, IND #116598), A Novel Soluble Recombinant Activin Receptor-Like Kinase 1 (ALK-1) Inhibitor Receptor-Fusion Protein, in the Treatment of Persistent or Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma
GOG 0186H A Randomized Phase II Evaluation of Weekly Paclitaxel Versus Weekly Paclitaxel with Oncolytic Reovirus(REOLYSIN® NSC # 729968, BB-IND # 13370) in the Treatment of Recurrent or Persistent Ovarian, Fallopian Tube or Primary Peritoneal Cancer
Cervix
CASE 4812 Randomized Phase II Study of Intravenous 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone (3-AP, Triapine NSC #663249) Cisplatin-Radiochemotherapy Versus Intravenous Cisplatin-Radiochemotherapy in Women Diagnosed with Stage IB-IVA Cervical Cancer and Stage II-IVA Vaginal Cancer
Ovary, Sex Cord Stromal Tumor
GOG 0264 A Randomized Phase II Trial Of Paclitaxel and Carboplatin vs. Bleomycin, Etoposide, and Cisplatin for Newly Diagnosed Advanced Stage and Recurrent Chemonaive Sex-Cord Stromal Tumors
Leiomyosarcoma
GOG 0277 A Phase III Randomized Trial of Gemcitabine (NSC# 613327) plus Docetaxel (NSC# 628503) followed by Doxorubicin (NSC# 123127) v. observation for uterus-limited, High Grade Uterine Leiomyosarcoma
Vulva
GOG 0279 A Phase II Trial Evaluating Cisplatin (NSC #119875) and Gemcitabine (NSC # 613327) Concurrent with Intensity-Modulated Radiation Therapy (IMRT) in the Treatment of Locally Advanced Squamous Cell Carcinoma of the Vulva
Non-Cancer Treatment and Surgical Studies
GOG 0244 The Lymphedema and Gynecologic Cancer (LEG) Study: Incidence, Risk Factors, and Impact in Newly Diagnosed Patients
CASE 9812 Acquisition of Human Gynecologic Cancer Specimens and Serum to Study the Causes, Diagnosis, Prevention, and Treatment of Gynecologic Cancers
GOG 0225 Can Diet and Exercise Modulate Ovarian, Fallopian Tube and Primary Peritoneal Cancer Progression-Free Survival?
CARI 1Z12 A Registry of Caris Target Now™ Test Results (Biomarker Expression Patterns) for Evaluation of Correlation with Clinical Outcomes for Cancer
CASE 5811 REWARD (Revving-Up Exercise for Sustained Weight Loss by Altering Neurological Reward and Drive): A Randomized Trial of Assisted Exercise in Obese Endometrial Cancer Patient
GOG 0278 Evaluation of Physical Function and Quality of Life (QOL) Before and After Non-Radical Surgical Therapy (Extra Fascial Hysterectomy or Cone Biopsy with Pelvic Lymphadenectomy) for Stage IA1 (LVSI+) and IA2-IB1
CASE 13813 Referral of Obese Endometrial Cancer Survivors to a Bariatric Specialist and a Healthier Survivorship: A Prospective Intervention Cohort
RTOG Trials
CASE 13813 Referral of Obese Endometrial Cancer Survivors to a Bariatric Specialist and a Healthier Survivorship: A Prospective Intervention Cohort

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