Case Western Reserve University School of Medicine has contributed several historical breakthroughs in the fields of medicine and health. The School boasts eight Nobel laureates among its faculty and alumni. Former professor of physiology John J.R. Macleod, FRS, was awarded the Nobel Prize for Physiology and Medicine in 1923 for discovering insulin. Case Western Reserve Alumnus (BS '51) Paul C. Lauterbur, PhD, shared the Nobel Prize for Physiology and Medicine in 2003 with Sir Peter Mansfield, PhD, FRS, for discoveries in magnetic resonance imaging. Other notable research accomplishments by School of Medicine faculty members include: the first surgical treatments of coronary artery disease, the first simulated milk formula for infants, development of the first heart-lung machine for use in open heart surgeries, the first successful genetic alteration of human cells in a test tube, and creation of the first artificial human chromosome.
Today, research being conducted at the School is just as innovative. Recent studies have covered everything from the molecular basis of Alzheimer's disease, to examining infectious diseases of the developing world, and creating the first stool test that detects colon cancer. In recognition of this continued commitment to innovation, the School of Medicine was awarded $64 million from the National Institutes of Health/National Center for Research Resources to form the Clinical and Translational Science Collaborative right here in Ohio. When the award was renewed for five years and increased to $64.6 million in 2012, it broke a record the original grant set as the largest-ever in Northeast Ohio.
Collaboration is key to this ongoing success. Case Western Reserve University School of Medicine is affiliated with some of the best hospitals in the United States, and is committed to developing a research portfolio that is aligned with their strategic clinical initiatives. A primary affiliation with University Hospitals, and formal partnerships with Cleveland Clinic, the Louis Stokes Cleveland VA Medical Center, and the MetroHealth System ensures a cooperative network that is a true powerhouse.
Through these partnerships, several cutting-edge technologies and research facilities are available to faculty and students. Core facilities of the School are the Case Medical Center, which comprises Case Western Reserve University and University Hospitals Health System, the Cleveland Clinic Lerner Research Institute, and the MetroHealth Medical System Rammelkamp Center for Education and Research. Further top-notch resources include the Case Center for Imaging Research, Case Comprehensive Cancer Center, Center for Aids Research, National Prion Disease Pathology Surveillance Center, Center for Proteomics and Bioinformatics, the Center for Global Health and Disease.
Maintaining such a high standard of biomedical research means the School of Medicine must continually look to the future. Upcoming objectives include developing a program in population health and personalized medicine, creating a Center for Membrane Biology, forming a Sleep Research Center and Sleep and Circadian Research Program, establishing a Center for Translational Therapeutics and Chemical Biology, enhancing the Systems Medicine Program, and creating a Silvio O. Conte Digestive Diseases Research Core Center.