NHLBI Grant Funds Study of Red Blood Cell Transfusions

A $3.9-million grant has been awarded to support the work of Jonathan Stamler, MD, director of the Institute for Transformative Molecular Medicine and the inaugural Robert S. and Sylvia K. Reitman Family Foundation Chair in Cardiovascular Innovation at the Case Western Reserve University Cardiovascular Center and University Hospitals Harrington-McLaughlin Heart & Vascular Institute.

The grant is one of nine funded by the National Heart, Lung and Blood Institute (NHLBI) to assess the safety and effectiveness of red blood cell transfusions, which have been increasingly associated with heart attacks, organ failure and death. Stamler's team will study whether restoring levels of S-nitrosohemoglobin—a compound that helps regulate blood flow—in stored blood improves tissue oxygenation.