Working independently, the faculty member will carry out complex and advanced research studying bioelectronic interventions to target organ health, with the overall goal of developing a system to monitor, prevent, and treat cardio-respiratory and related disorders. Specifically, the Assistant Professor will examine the potential of peripheral nerve stimulation as a treatment modality for conditions such as hypertension, diabetes and sleep apnea.
In addition, the faculty member will be responsible for securing independent funding and will serve as the Principal Investigator for grant funded projects.
This position will work with animals and involve both acute and chronic experiments.
- Conduct and oversee laboratory research activities to examine electrical stimulation of peripheral nerves (i.e., cervical sympathetic chain, renal, vagus) as potential treatment for disease conditions.
- Develop new experimental techniques to facilitate nerve stimulation studies.
- Assess outcomes of acute and chronic nerve stimulation using electromyogram, electroencephalogram, plethysmography and other electrophysiology measures.
- Utilize new and innovative research techniques involving a high degree of skill and training.
- Anticipate, troubleshoot and correct potential difficulties in carrying out research projects.
- Organize and analyze all data resulting from these studies.
- Write and submit grants for independent funding.
- Author and co-author journal articles on research projects.
- Present results at national meetings, as well as in Pulmonary Grand Rounds, Sleep Medicine Grand Rounds and Department of Medicine Grands Rounds settings.
- Participate in mentoring committees for Pulmonary and Sleep fellows currently conducting research.
- Read and stay up to date in current scientific reports concerning research topics related to the laboratory’s projects.
- Monitor the laboratory budget, consult with supervisor and administrator to ensure laboratory funds are well managed.
- Supervise and direct post-doctoral researchers, graduate students and research assistants employed by the lab, as well as pulmonary fellows who rotate through the lab.
- Prepare and modify protocols for performance of animal research. Prepare reports for maintenance of these approvals.
- Instruct and direct new lab personnel in the techniques and procedures necessary to carry out the research projects of the laboratory.
- Direct, oversee and perform routine maintenance within the laboratory, including cleaning of equipment and lab ware, discarding biohazardous waste, and order supplies.
- Maintain laboratory certifications for general lab safety, biohazard handling, chemical safety, and handling of infectious pathogens.
- Prepare and modify protocols for performance of animal research (IACUC protocols) and periodic reports for maintenance of these approvals.
- Perform other duties as necessary.
Department: Periodic contact with Pulmonary Division Chief (supervisor), other division personnel and laboratory staff; occasional interaction with department officials involved in protocol review and approval
University: Regular interaction with internal and external collaborators and other investigators, and moderate interactions with university officials involved in supervising laboratory safety, in budgets, purchasing, and in approving protocols for animal research
External: Frequent interaction with outside collaborators (especially Galvani Bioelectronics) and with suppliers and manufacturers of materials used in the laboratory
Students: Infrequent interactions with students other than those who may work in the laboratory.
Direct supervisory responsibility for post-doctoral associates, graduate students and research assistants who work in the laboratory.
Experience: 10 years of experience conducting independent research projects in animal physiology, peripheral nerve stimulation or related topics.
Education/Licensing: PhD and/or MD in physiology, anatomy, pharmacology or related area required.
- Knowledge, understanding of and proficiency in commonly-used concepts, practices, and procedures within the fields of physiology and biophysics, including but not limited to animal surgery (acute and chronic), anatomy, device implantation, nerve tract tracing, immunohistochemistry, immunofluorescence microscopy.
- Advanced surgical skills, including in vivo and in situ vagal, cervical sympathetic, hypoglossal, splanchnic sympathetic, phrenic and pelvic nerve isolation for recording and stimulation in rats and mice, chronic nerve electrode implantation, electromyogram recording (EMG; diaphragm, genioglossus, external urethral sphincter), electroencephalogram recording (EEG), rodent anesthesia delivery, recovery surgery care and observation.
- Plethysmography (whole-animal ventilatory measurements).
- Proficiency using nerve stimulators, stimulation isolation units, knowledge of stimulation paradigms and variables.
- Proficiency in Spike data analysis software (Cambridge Electronic Design).
- Basic laboratory skills including, but not limited to, pipetting, centrifugation, aliquoting, typical laboratory mathematic calculations
- Must be compliant with Animal Resource Center (ARC) policies and procedures, as well as with regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines for animal research.
- Strong organization skills; ability to multi-task, prioritize and meet strict deadlines. Must demonstrate attention to detail and accuracy, time management skills, and follow-through.
- Strong interpersonal skills; ability to work and communicate with various individuals from a broad spectrum of disciplines, technical and educational backgrounds within the department, school and university, and with individuals outside the university.
- Ability to work effectively, independently and collaboratively within a team. Must be highly motivated, responsible, and dependable.
- Effective problem-solving skills; must demonstrate excellent analytical skills, sound judgment and good decision-making.
- Strong computer skills (database applications, graphics and presentations, internet)
- Must demonstrate willingness to create or learn new techniques, procedures, processes, and computer programs as needed in order to progress research.
- Professional and effective verbal and written communication skills.
The position requires work with pre-clinical animal models in a basic science laboratory. The position, therefore, requires annual retraining in principles of performing animal research and handling of blood borne pathogens. This is an exempt position and hours are not limited to 40 hours/week. Travel to present research results at scientific meetings will be required.
Interested candidates should apply by sending a CV, a cover letter, a statement of research plans and the names of three references to: Frank Jacono, MD, Search Committee Chair, Division of Medicine, Biomedical Research Building Room 347, 10900 Euclid Avenue, Cleveland, OH 44106 or firstname.lastname@example.org.
In employment as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office for Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.