Supervisor Name and Title: Peder Lund, PhD, Assistant Professor
I. STATEMENT OF RESEARCH AND SCIENTIFIC RESPONSIBILITIES
- We seek a highly motivated and skilled researcher with an interest in host-microbiota interactions to join our newly established lab as a post-doc with an anticipated start date in March 2023 or earlier. Using experimental models involving cells, organoids, and mice, the qualified candidate will investigate how the gut microbiota interacts with the host intestinal epithelium to promote homeostasis and how these interactions become altered in pathological states, like inflammatory bowel disease (IBD). Specific areas of interest include understanding the functional impact of microbiota-derived small molecules on host physiology, including cell metabolism and gene expression. The qualified candidate will also be encouraged to develop new and independent lines of inquiry based on the outcomes of these studies.
- The qualified candidate will utilize modern approaches in biochemistry, molecular biology, and microbiology. These are expected to involve but are not limited to: cell and organoid culture; cloning; transfection and retroviral transduction; genome editing; qPCR; immunoblotting; purification of biological molecules (DNA, RNA, protein, and/or metabolites) from cells and tissues; mouse models; liquid chromatography and mass spectrometry; bacterial culture (including anaerobic culture); and 16S sequencing.
- As a post-doctoral research associate, the qualified candidate is expected to present data at departmental seminars and scientific meetings, prepare manuscripts, and contribute preliminary data for grant proposals.
II. TECHNICAL SKILLS
- Experience with mouse models (animal care and breeding, genetic manipulation and genotyping, oral gavage, and/or tissue collection) is strongly preferred.
- Experience with mammalian cell culture is strongly preferred.
- Proficiency in cloning, transfection, viral transduction, and/or CRISPR-Cas9 genome editing is strongly preferred.
- Experience with anaerobic culture of microbes is desirable but not required.
- Experience with liquid chromatography, mass spectrometry, and stable isotope tracing is desirable but not required.
- Basic knowledge of gut physiology and the microbiota is desirable but not required.
III. SUPERVISORY RESPONSIBILITIES
- Supervise laboratory technicians, visiting scholars and student trainees in experimental design and data analysis of a variety of projects as required by the PI.
IV. EDUCATION REQUIREMENTS
- Minimum qualifications include a Ph.D. (or Ph.D. expected by March 2023) in microbiology, biochemistry, genetics, or a related field in the biological sciences.
- Prior laboratory research experience is required.
- A background in mouse genetics and/or microbiome science is highly preferred but not required.
- The successful candidate must have strong reasoning, analytical, and communication (both oral and written) skills as evidenced by first-author publications in peer-reviewed journals, presentations at scientific meetings, and/or successful funding applications.
V. HOW TO APPLY
- To apply, send a CV, cover letter describing your qualifications and interest in the position, and the names and contact details of 3 references to Dr. Peder Lund, email@example.com.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis