Post-Doctoral Research Position In Structural Biology, Department of Pharmacology

A post-doctoral research position is immediately available in the lab of Jason Mears. This position involves interdisciplinary and collaborative research using high-resolution cryo-EM. In the Mears Lab, we study structure-function relationships for proteins that drive mitochondrial membrane fission. Mitochondrial dynamics play a critical role in maintaining the health of eukaryotic cells, and defects in mitochondrial morphology are associated with an increasing number of human diseases, including neurodegeneration and cancer. 

About the Mears Lab

The Mears Lab is ideally situated in the Center for Mitochondrial Diseases. Additionally, our group has unlimited access to a state-of-the-art cryo-EM facility housed in the Cleveland Center for Membrane and Structural Biology (CCMSB). Users will have access to a JEOL 2200FSC equipped an Omega filter and a BioQuantum K3 camera, a TF20 equipped with a Teitz 4K camera, and a T12 with a 4K camera. Additional resources for specimen preparation and image processing are in place. A major goal of the CCMSB research groups is to enhance the structural biology research community and to provide expertise in cryo-electron microscopy (cryo-EM), nuclear magnetic resonance spectroscopy (NMR), X-ray crystallography, proteomics, and a variety of related biophysical techniques. Importantly, our goal is to provide hands-on training in the broad range of structural biology methods to trainees.


A successful candidate will work collaboratively to define molecular interactions that drive membrane remodeling. Applicants should hold a PhD (or be within ~6 months of holding a PhD) in the area of biochemistry, biophysics, molecular biology or a related area. Experience with cryo-EM and image processing is preferred, but not required.


Applicants should send a brief cover letter that describes previous research experience, a CV and contact information for 2-3 references to

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity.  Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

Case Western Reserve University provides reasonable accommodations to applicants with disabilities.  Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation.  Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.