Post-Doctoral Research Scholar, Radiation Oncology

Date: 3/18/2019

Title: Post-Doctoral Research Scholar

Department: Radiation Oncology

School: Medicine

Location: BRB and Wolstein Research Building

Supervisor Name and Title: Mitchell Machtay, M.D., Professor/Chair Radiation Oncology;  and Serah Choi M.D. Ph.D., Assistant Professor, Radiation Oncology

 

POSITION OBJECTIVE

The candidate will be working within the field of radiation oncology and responsible for the development and implementation of radiation oncology translational research activities in the Case Western Reserve University Case Comprehensive Cancer Center. Dr. Mitch Machtay is the Chair of Radiation Oncology at University Hospitals. Dr. Serah Choi is a physician-scientist and a CNS radiation oncologist at University Hospitals. The core objective of Dr. Choi’s laboratory is to develop novel therapeutic strategies in the management of brain metastases, with an emphasis on mechanisms of radiosensitization and immunomodulation. The scientist will investigate innovative radiation combined modality techniques (studying pharmacologic agents with radiotherapy) to improve the efficacy of radiotherapy.  Emphasis will be on in-vitro (patient-derived human tissue) and in vivo mouse experiments (xenograft and syngeneic) for models related to lung cancer and brain tumors. A major mission of the laboratory is to translate laboratory-derived findings into clinical trials/practice.

 

ESSENTIAL FUNCTIONS

  1. Development of brain metastases laboratory models. Design, plan and carry out in vitro and in vivo experiments in collaboration with PI (Dr. Machtay) and co-PI (Dr. Serah Choi). (80%)
  2. Responsible for general lab operations including inventory, lab organization and maintain certain equipment/facilities.  Ensure the lab procedures are in compliance with policies, procedures and regulations of the Animal Resource Center, IACUC, Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines of the organization. Coordinate laboratory meetings. (10%)

 

  1. Assist in grant-writing and abstract/manuscript writing activities (10%).

NONESSENTIAL FUNCTIONS

  1. Perform other duties as assigned by the PI and co-PI.

 

CONTACTS

Department: Admin staff- occasional;

University: Environment health and safety, Animal Research- External: Collaborators- Occasional

Students: Graduate and undergraduate- Occasional

 

SUPERVISORY RESPONSIBILITY

Supervisory responsibility for research associates/technicians and visiting scholars currently working in the laboratory and potentially students (undergraduate, medical students and/or graduate students) who will be joining the lab.

 

QUALIFICATIONS

This position requires a PhD degree in a biomedical specialty such as cancer biology, molecular biology, pharmacology, microbiology, immunology, etc and an interest in radiation biology.  Extensive experience with tissue culture and mouse models is required. A background in immunology, genomics, proteomics, bioinformatics and/or flow cytometry is highly desirable.

 

REQUIRED SKILLS

 

  1. Highly motivated. Passionate about research. Ability to independently drive projects.
  2. Ability to collect and analyze data with attention to detail and accuracy.
  3. Effective oral and written communication skills. Must be able to effectively communicate with the PI/supervisor as well as other lab members.
  4. Ability to supervise and/or train other researchers within the laboratory.
  5. Good interpersonal skills; ability to work and communicate with various individuals within and external to the University. Collaborative.
  6. Good organization skills; ability to multi-task, prioritize and meet deadlines.
  7. Ability to operate laboratory equipment and learn to operate new instruments.
  8. Familiarity with policies and procedures of lab and chemical safety.
  9. Willingness to learn new techniques, procedures, processes, and software programs as needed.

 

WORKING CONDITIONS

The primary work environment will be in a cancer biology ‘wet lab,’ with typical associated potential chemical and biological biohazards.  Appropriate training and precautions are a priority of this work environment. 

 

HOW TO APPLY

Please send application materials to serah.choi@uhhospitals.com.