Post-Doctoral Scholar - Case Cardiovascular Research Institute

The Case Cardiovascular Research Institute at Case Western Reserve University School of Medicine and the Harrington Heart & Vascular Institute at University Hospitals seeks to hire a post-doctoral fellow. Candidates with research programs in molecular control of immunity, metabolism, circadian rhythm and atherosclerosis with translational relevance to human disease are of particular interest.

 

The candidate will play a leading role in the design, implementation, and analysis of experiments in mouse models to improve our understanding of how epigenetic factors shape immune responses, circadian dysregulation in response to environmental stressors. We are particularly interested in the immune interface of metabolic/circadian alterations and epigenetic control of these pathways. We are developing novel approaches to probe cell-type specific epigenetic changes in complex tissues using techniques including microdissection, fluorescence-activated nuclear sorting, DNA methylation analysis by whole-genome bisulfite sequencing, and transcriptional profiling (e.g., RNA-seq and ChIP-seq, Bisulfite-seq).

 

The successful candidate will be anticipated to have a strong background in animal models and in-vivo physiology with an emphasis on metabolic characterization. Expertise in FACS/Flow Sorting and single cell isolation approaches and experience with analytical approaches to high-volume genomic, epigenomic, and gene expression data is a strong plus. The successful candidate is expected work independently and take a leading role in data analysis, interpretation, and visualization, and drafting of manuscripts for publication.

 
Please e-mail curriculum vitae, summary of research accomplishments and outline of future research directions to Sanjay Rajagopalan, Professor Director CVRI, Case Western Reserve School of Medicine (sxr647@case.edu and/or Vinesh Vinayachandran, Assistant Professor, CVRI; vxv154@case.edu).

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

 

Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

 

Key words: bioinformatics, bisulfite-seq, diabetes, atherosclerosis, metabolism, computational biology, DNA methylation, epigenetics, epigenome, epigenomic, circadian, environment, human, hypothalamus, mammalian, mouse, neuroscience, next-generation sequencing, nutrition, obesity, postdoc, physical activity