Post-Doctoral Scholars – Division of Cancer Biology, Department of Medicine, MetroHealth Research Center

Post-Doctoral Scholars – Division of Cancer Biology, Department of Medicine, MetroHealth Research Center, Case Western Reserve University School of Medicine

POSTDOCTORAL SCHOLAR – MH Research – Cancer Biology

Location: Rammelkamp Center for Research and Education, MetroHealth Medical Center

Available Date: March 1, 2021

Supervisors: Dr. Chengfeng Yang; Dr. Zhishan Wang

The Yang Lab and Wang Lab at Division of Cancer Biology of Department of Medicine in MetroHealth Research Center have several NIH grants-funded Postdoctoral Scholar positions. The postdoc scholars will work on one or more projects to: (1) Investigate the mechanism of carcinogen-induced lung carcinogenesis; (2) Study the mechanism of triple negative breast cancer metastasis; and (3) Develop new cancer therapies (drug repurposing, nanoparticle- mediated drug delivery and its combination with radiation therapy and immunotherapy). The mechanistic studies focus on the roles of epigenetic dysregulations including DNA methylation, histone posttranslational modifications, non-coding RNA (especially long non-coding RNAs) and functional RNA modification (m6A) dysregulations in cancer initiation, metastasis and therapeutic responses using cell culture and genetically modified mouse models. Competitive salaries and benefits will be provided to qualified candidates. Candidates should have a recent Ph.D. degree with strong background in cell/molecular biology, cancer biology, immunology, toxicology or chemistry. Experiences in studying cancer epigenetics, non-coding RNAs especially long non-coding RNAs, functional RNA modifications especially the m6A modification, cancer stem cells, nanoparticle-mediated drug delivery or immunotherapies with excellent skills in cloning and manipulating genes, culturing mammalian cells, handling mice, performing surgeries to produce tumors in mice and treating mice with commonly-used drug/toxicant administration approaches would be advantageous. In addition, the qualified candidates are expected to be highly self-motivated with strong interests in learning new knowledge and techniques; have excellent communication and organizational skills and attention to details; be capable of conceptualizing, designing experiments and conducting studies independently as well as cooperatively with other lab members as a team; and have the capability to write manuscripts for quality publications.

MAJOR DUTIES AND RESPONSIBILITIES

  1. Design, execute, and record laboratory experiments; apply standard scientific protocols to experiments, research, and improve current methods and evaluate innovative techniques.
  2. Draft, write, and edit scientific reports, papers, journal articles, and abstracts.

 

  1. Design and perform experiments and record data according to research protocol. Independently reproduce, evaluate, research, and improve techniques currently used. Adapt new methods to existing procedures and modify current experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all laboratory work and experiments.
 
  1. Develop, set-up, and verify new procedures in the laboratory. Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols, design formats.

 

  1. Discuss relevant insights about experimental results with Faculty and provide useful recommendations and analysis.

 

  1. Maintain an integral role in the laboratory's meetings, presentations, and publications. Present information on research and laboratory work to others at laboratory meetings, journal clubs, and seminars.

 

  1. Troubleshoot and correct erroneous results or problems with laboratory equipment. Maintain and repair equipment; monitor proper use by personnel.

 

  1. Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks.

 

  1. Assist in preparing, writing, and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests; track funding, maintain accurate balance, and resolve any discrepancies.

 

  1. Follow policies and procedures governing the handling of confidential information as defined by Case Western Reserve University’s mission and applicable laws and regulations. Ensure timeliness, accuracy, availability, and security of information.

 

  1. Perform routine procedures, including the collection and analysis of research data, which may affect decisions regarding future patient care.

 

  1. Provide services in a manner to be regularly and conveniently available to meet the needs of Case Western Reserve University’s research initiatives as determined by department management and their governing body.

 

  1. Maintain currency in field through continuing education, literature, and seminars. Implement this knowledge into the Department.

 

  1. Recommend approaches for improvement activities, recommend, and perform new processes, collect, and measure data, develop processes based on performance, and communicate results.

 

  1. Understand, adhere to, and model Core Standards as defined organizationally and specifically within the department/unit.

 

  1. Perform other duties as assigned.

 

EDUCATION/EXPERIENCE

Required: A recent PhD or equivalent doctoral degree.

Preferred: A strong background in cell and molecular biology, cancer biology, toxicology, chemistry or molecular immunology is preferred.

Interested applicants should submit a complete CV, a cover letter of interest describing your research training/experience and future career goal and provide names/contact information of three individuals that can provide academic references upon request to: Dr. Chengfeng Yang: Chengfeng.yang@case.edu and Dr. Zhishan Wang: Zhishan.wang@case.edu

 

DIVERSITY STATEMENT

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Competitive salary commensurate with experience, and benefits; NIH funded.