Regulation of CFTR gene expression
Department of Genetics and Genome Sciences
Case Western Reserve University
Cleveland, Ohio. USA
Errors in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are associated with the common inherited disorder cystic fibrosis. This gene has a complex pattern of tissue specific and temporal regulation (reviewed in Gosalia and Harris 2015, Genes 6, 543-558). We recently showed the differential contribution of cis-regulatory elements to the higher order chromatin structure and expression of the locus (Yang et al. 2016, Nucleic Acids Research 44, 3082-3094). Our current goals are 1) to determine the mechanisms of action of novel tissue specific and developmental regulatory elements in CFTR; and 2) to develop novel therapeutic approaches that target CFTR gene regulatory mechanisms.
Successful applicants for this NIH/CFF funded program will have a strong record of accomplishment as shown by publications as a graduate student and/or postdoc, be highly motivated and have a passion for human genetics/gene regulatory mechanism research. Expertise in one or more of the following areas is required: familiarity with use of public genome browsers and large data repositories; state of the art genomics technologies including ChIP-seq, RNA-seq, ATAC-seq, 4C-seq and the use of relevant bioinformatic pipelines; transcription factor biochemistry, CRISPR/Cas9 genetic manipulations.
Familiarity with general techniques of molecular biology and mammalian cell biology is essential. We are part of a vibrant and interactive research community at Case Western Reserve University and occupy excellent, modern laboratory space.
Please send an electronic letter of application, quoting the reference CWRU/AH3/2017, Curriculum Vitae and contact information of 3 referees to: firstname.lastname@example.org. Hiring is contingent upon eligibility to work in the United States.
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