New position available in the translational lab of Dr. Afshin Dowlati, M.D., focused on small cell lung cancer (SCLC) research. This newly funded project centers on the role of the retinoblastoma protein in chemo-refractory disease. The goals are to delineate biomarkers which may identify these patients upfront and to develop new therapies with efficacy in this cohort. Chemo-response will be correlated with biomarker expression in a large cohort of tumor specimens using IHC and RNAscope analysis. Both cell culture and PDX models of SCLC will be used to investigate the molecular mechanisms underlying therapeutic responses to various drugs. Candidate should have hands-on experience with most cell and molecular biological procedures basic to tumor cell biology: cell culture, western blotting, cell proliferation and death assays, RNA/DNA isolation, qPCR, luciferase assays, FACS, etc. Knowledge of bioinformatics and/or epigenetic techniques a plus. Future directions may include opportunities to develop a SCLC GEMM. Candidate must be a self-motivated, critical thinker with a good work ethic, excellent written and oral communication skills, and a collaborative demeanor. Will be expected to apply for their own future funding once established. The current research team consists of one program manager (Ph.D), a clinical database coordinator (MPH), a Ph.D. graduate student and two technicians (B.S.). The research environment is outstanding and is based in the Case Comprehensive Cancer Center.
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