Position Objective. The Department of Pathology at Case Western Reserve University School of Medicine seeks a highly motivated postdoctoral scholar to conduct research in the laboratory of Dr. Stanley Adoro. The Adoro lab studies proteostatic mechanisms that regulate immune cell homeostasis, function and diseases. Combining cutting edge technologies in proteomics and genomics with innovative animal models that allow targeted modulation and tracking of candidate genes, we seek to understand the molecular mechanisms by which the unfolded protein response (UPR) and the ubiquitination machinery modulate T-cell and hematopoietic stem cell activity and the emergence of blood cell diseases including leukemia and autoimmunity.
The applicant must have a PhD or MD/PhD degree in Immunology and/or Molecular/Cell Biology with a record of productivity evidenced by scholarly publications. Interested individuals should send a cover letter, CV, and contact information of three people who could provide recommendation letters of reference by email to firstname.lastname@example.org.
As a Postdoctoral Scholar, the candidate is expected to:
- Design, plan, and carry out experiments under PI supervision to elucidate the function of UPR proteins in bone marrow hematopoietic stem cell activity and myeloid leukemia.
- Perform rodent experiments and husbandry including bone marrow chimeras, breeding, genotyping and maintain an accurate animal database.
- Rigorously document experimental results and present results in laboratory meetings, departmental seminars and scientific conferences.
- Prepare manuscripts and contribute preliminary data for grant proposals.
- Work closely with other lab members to ensure projects are being completed according to the research plan and in organizing laboratory space and supplies.
- Work with PI to submit and manage compliance with policies, procedures and regulations of the Animal Resource Center, IACUC, lab safety policy, and other applicable regulatory guidelines for which essential training will be provided.
Train and oversee rotation students and other research staff in the lab.
PhD in Immunology or biomedical sciences with hands-on experience in immunology, molecular cell biology and animal work.
YEARS OF RELEVANT EXPERIENCE REQUIRED
PhD with 0-2 years of postdoctoral experience.
PROPOSED SALARY RANGE
NIH salary scale.
- Experience in cell culture of primary cells and established cell lines of mouse and human hematopoietic stem and progenitor cells.
- Experience in immunology techniques notably multi-panel flow cytometry.
- Experience in molecular cloning, molecular & cell biology techniques.
- Experience with handling and working on animal model experiments.
- Ability to work independently after essential training has been provided.
- Effective oral and written communication skills.
- Flexibility in work schedule to complete necessary study within deadlines.
Qualified candidates should send their CV, cover letter, and three professional references to Dr. Stanley Adoro (email@example.com).
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.