We are a highly translational lab led by the Chief of Surgical Oncology, with NCI funding in place for the next 7 years. Pancreatic cancer is the most aggressive of the common cancers, with the worst survival and is expected to be the second leading cause of cancer death in the next decade. We are focused on helping to solve this problem, and eager to identify a post-doc with the same aspiration. Importantly, the post-doc must work well with others, and have a desire to help cancer patients as a principal motivation for their work. The post-doc position is a key one within the lab. The post-doc will work closely with the PI to lead these efforts, and will be responsible for planning and execution of experiments. The lab works closely with other PI's at the Case Comprehensive Cancer Center, as well as clinical departments at University Hospitals, including collaborations with a multidisciplinary team of biologists, statisticians, and clinicians. The qualified candidate will prepare manuscripts and contribute preliminary data, background and significance and experimental design for grant proposals. The work focuses more specifically on understanding how pancreatic cancer cells adapt to survive and thrive in a harsh metabolic milieu, and additionally how metabolic reprogramming confers resistance to both conventional chemotherapy and novel immunotherapies. Additional projects in the lab include the development of novel drug discovery platforms, and studying molecular mechanisms that underlie pancreatic cancer-associated depression. Lab work will involve tissue culture; DNA, RNA, and protein-related assays; drug-sensitivity assays, and small animal work. Additionally, studies will interface with experts in pathology, biostatistics, medicinal chemistry and other specialties. The candidate should be able to work independently, read and critically interpret the literature, assist with designing and planning of projects, oversee collaborations, supervise students, manage animal models, and to carry out research on the assigned project. They will also be encouraged to apply for grants to gain experience and support future projects.
1. Design, plan and carry out experiments in collaboration with PI. Provide assistance and oversight of staff, and graduate students ensure projects are being completed according to the research plan. Advise/Assist in developing improved techniques, project methods, or procedures.
2. Oversee general lab operations including inventory, lab organization and maintain certain equipment/facilities. Must demonstrate compliance with policies, procedures and regulations of the Animal Resource Center, IACUC, Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines for which essential training will be provided.
3. Analyze and record results. Assist in manuscript preparation.
4. Perform/supervise rodent husbandry including breeding, genotyping and maintain an accurate animal database.
5. Present results in laboratory meetings and other scientific meetings.
6. Plan and execute research in collaboration with other investigators on and off campus.
7. Develop and adapt laboratory techniques.
8. Analyze the data generated from these experiments and provide high level analysis to PI.
9. Develop and maintain an external reputation through activities such as publishing in high quality peer-reviewed journals, refereeing and conference presentations.
10. Support writing grant applications, research protocols, publications
11. Assist with management of daily laboratory operations and training of new students and staff.
1. Assist to manage lab wastes, organize lab inventory and take care of lab safety.
2. Perform other duties as assigned.
PI: Continuous contact with Principal Investigator for mentorship and collaboration
Lab colleagues: Continuous contact with lab members for collaboration. Lab members are encouraged to help, and to ask for help.
Department: Moderate administrative staff contact to obtain administrative support for research activities.
University: Routine contact with Environmental Health and Safety, as well as Animal Research in order to meet regulatory requirements.
External: Continuous contact with Collaborators to further our and their research objectives.
Students: Regular contact with graduate and undergraduate students as part of the teaching mission.
Supervisory responsibilities principally will include mentorship of students in the lab.
Experience: Graduate degree, PhD, in one of the fields related to biomedical or the life sciences, as preparation for a post-doctoral fellowship in cancer research.
1. Ability to work well with others and to work independently. The individual should be able to follow directions and protocols.
2. Ability to collect and analyze data with attention to detail and do multiple tasks simultaneously.
3. Effective oral and written communication skills. Must be able to effectively communicate with the PI/supervisor as well as other lab members.
4. Good interpersonal skills; ability to work and communicate with various individuals within and external to the University.
5. Good organization skills; ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy and follow-through on assigned tasks.
6. Ability to work effectively independently and collaboratively within a team.
7. Ability to work with sensitive information and maintain confidentiality.
8. Good problem-solving skills; must demonstrate good analytical skills, sound judgment and good decision-making.
9. Ability to rely on and follow instructions and pre-established guidelines to perform the functions of the job.
10. Ability to operate laboratory equipment and learn to operate new instruments
11. Familiarity with policies and procedures of lab and chemical safety
12. Knowledge in Microsoft Office, database applications, and with internet navigation.
13. Willingness to learn new techniques, procedures, processes, and software programs as needed.
Mostly, the researcher will work at the bench performing experiments that requires long time standing and sitting. Will perform some experiments in the animal room, standing in the laminar flow hood. Involves walking between different buildings in the University. Will involve travel to meetings or conferences if secured travel funding. Must be willing to adjust working hours according to the nature of ongoing experiments and many times work extended hours to finish the experiments. Working on weekends and holidays are required depending on the ongoing experiments and need to accelerate data generation and data collections.
Qualified candidates should send their CV, cover letter, and three professional references to Dr. Jordan Winter: Jordan.Winter@uhhospitals.org
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.