The laboratory of Dr. Jiri Safar in the Department of Pathology at the Case Western Reserve University School of Medicine (CWRU) has a postdoctoral position available under the NIH R01 5-year grant in collaboration with the Department of Physiology and Biophysics at CWRU. The laboratory utilizes cutting edge biophysical and genetic tools including transgenic mice, to study the mechanism of formation of prions and prion-like amyloids, their evolution and selection in the pathogenesis of Alzheimer’s and prion diseases. The Safar’s team has recently synthesized the first artificial human prion [Kim et al., Nature Communications (2018) 9:2166] and ongoing projects are focusing on defining the mechanisms of prion formation and replication in different human prion strains. The project would be ideally suited to a postdoctoral fellow with Ph.D. or M.D., and experience in mass spectroscopy-based proteomics of protein misfolding diseases, and biochemistry of prions and prion-like proteins.
Qualified applicants should submit a Cover Letter, current CV, and names and contact information for 3 references to: Jiri.Safar@case.edu
Categories: Alzheimer's disease, Structural Biology, Biochemistry, Biomedical Sciences, Neuroscience, Postdoctoral.
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