Date: November 2022
Title: Postdoctoral fellow
Department: Medicine, Division of Infectious Diseases and HIV Medicine
School: Case Western Reserve University School of Medicine
Location: Biomedical Research Building, 10th Floor
Supervisor Name and Title: Stephen Carpenter, MD, PhD, Assistant Professor
I. STATEMENT OF RESEARCH AND SCIENTIFIC RESPONSIBILITIES
The qualified candidate is responsible for performing and supervising research projects in the field of immunity to Mycobacterium tuberculosis. Specifically, the research will focus on T cell function and responses to tuberculosis using primary human cells and in vivo murine models. This includes experimental planning, data analysis, oral and written presentation of the results to the Faculty Mentor, collaborators or external parties, writing and revision of manuscripts for publications on scientific journals and of grants proposals for funding from the main funding entities (NIH, NCI) as well as foundations and private donors. Candidates should be highly experienced in standard immunology research techniques and handling of mice and human samples.
As a post-doc, he/she will work with a high level of independence, present data at departmental seminars and scientific meetings, prepare manuscripts, and apply for grant proposals. Managerial experience will be looked upon favorably
II. TECHNICAL SKILLS
- A high level of experience with standard immunology techniques is essential. Required techniques include: immunomagnetic cell isolation, flow cytometry, ELISA/ELISPOT, fluorescent microscopy, western blotting, PCR and qPCR
- Experience handling mice and human samples is required
- Knowledge and experience with a multitude of advanced techniques such as: PCR, RNA-seq, CRISPR / lentivirus design, immunohistochemistry staining and enzymatic activity assays.
- Experience with data analysis systems such as: Prism, Flowjo, microsoft excel, R and required packages (e.g. Seurat) is required
- Experience independently writing manuscripts for submission to peer-reviewed journals is required
- Experience with TCR sequencing and/or single-cell RNA sequencing is preferred
III. SUPERVISORY RESPONSIBILITIES
- Supervise laboratory technicians/assistants and student trainees in experimental design and data analysis of a variety of projects.
IV. EDUCATION REQUIREMENTS
- Minimum qualifications include a Ph.D. in immunology, microbiology or equivilent.
- Prior post-doctoral research experience is strongly preferred.
- Experience with in vitro human or murine live T cell assays, and in vivo assays in mouse models, flow cytometry, essential.
- The successful candidate must have strong analytical, oral and written communication skills.
- The successful candidate must keep organized records of experiments and analyzed results.
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