The laboratory of Dr. Jiri Safar in the Department of Pathology at the Case Western Reserve University School of Medicine has a postdoctoral position open to study biological, biophysical, and translational aspects of Alzheimer’s disease and neurodegenerative diseases caused by misfolded proteins. The position is available under the NIH 5-year grant award in collaboration with the Alzheimer’s Disease Center at the New York University Medical School.
The Safar laboratory utilizes cutting edge biophysical and genetic tools including transgenic mice to study the role of misfolded proteins in pathogenesis of neurodegenerative diseases. Our recent paper shows that the rate of progression in Alzheimer’s disease is linked to the distinct structural organization of amyloid beta. We have ongoing projects focusing on defining the mechanisms of this effect and coupling between different prion-like strains of amyloid beta, tau protein, and the disease phenotype. These projects would be ideally suited to a postdoctoral candidate with experience in experimental neuropathology of murine Alzheimer’s models, immunohistochemistry, fluorescence microscopy, and techniques of protein biochemistry.
Please submit CV, names and contact information for three references, and a description of your research experience to Dr. Safar Jiri.Safar@case.edu.
Categories: Alzheimer's disease, Neurodegeneration, Structural Biology, Biochemistry, Biomedical Sciences, Neuroscience, Postdoctoral.
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