Postdoctoral Scholar - Center for Synchrotron Biosciences, Department of Nutrition

Title: Postdoctoral Scholar

Department: Center for Synchrotron Biosciences, Department of Nutrition

Location: National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY

Supervisor Name and Title: Erik Farquhar, Research Scientist


The Case Western Reserve University Center for Proteomics and Bioinformatics (CPB, seeks applications for a talented, enthusiastic postdoctoral scholar to join our Center for Synchrotron Biosciences (CSB, team based full-time at the National Synchrotron Light Source II (NSLS-II, at Brookhaven National Laboratory on Long Island, NY. The CSB operates the 17-BM XFP Partner beamline at NSLS-II for synchrotron X-ray footprinting structural mass spectrometry methods, and promotes the application of this method and other synchrotron tools to a variety of structural biology problems. We have recently set up a nanoLC-MS system (Thermo Orbitrap Elite mass spectrometry coupled to a Waters nanoACQUITY UPLC) to enable mass spectrometric characterization of samples following beamline experiments. This allows all elements of the synchrotron X-ray footprinting experiment to be integrated within a single facility.

The successful applicant will participate to our synchrotron X-ray footprinting science and user support program. He/she will contribute to developing novel X-ray footprinting chemistries, further optimizing and accelerating the X-ray footprinting experiment workflow particularly the steps following the synchrotron experiment, and will oversee operation and support of the CSB’s in-house nanoLC-MS system. He/she will also work with the beamline support team to support day-to-day operation and ongoing technological developments at the NSLS-II XFP beamline.


Required technical skills include:

  • Hands-on experience with operation and maintenance of LC-MS instrumentation.
  • Experience with mass spectrometry data analysis in the life sciences.
  • Excellent background in structural biology, chemistry, or other related fields as evidenced by publication record and educational background.

Preferred technical skills include:

  • Experience with the operation of ThermoFisher mass spectrometers and Waters LC instruments.
  • Familiarity with / experience in synchrotron and laboratory-based structural biology methods.
  • Interest / skills in hands-on instrumentation development.
  • Experience / interest in Python programming for scientific applications.


Assist visiting scholars and students in the execution of X-ray footprinting experiments at the NSLS-II XFP beamline, including compliance with NSLS-II facility safety requirements.


Minimum qualifications include a Ph.D. in Chemistry, Biochemistry, Biophysics, or a related discipline. The successful candidate must have strong analytical, oral, and written communication skills.


This position is based full-time off-campus at the National Synchrotron Light Source II, a US Department of Energy user facility at Brookhaven National Laboratory on Long Island, NY. Evening and weekend work will be necessary from time to time.


To apply, send a CV, cover letter describing your qualifications and interest in the position, and the names and contact details of three references to Erik Farquhar,, XFP lead beamline scientist.


In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity.  Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

Case Western Reserve University provides reasonable accommodations to applicants with disabilities.  Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation.  Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.