Regulation of CFTR gene expression.
Errors in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are associated with the common inherited disorder cystic fibrosis. This gene has a complex pattern of tissue specific and temporal regulation (reviewed in Gosalia and Harris 2015, Genes 6, 543-558). We recently showed the differential contribution of cis-regulatory elements to the higher order chromatin structure and expression of the locus (Yang et al. 2016, Nucleic Acids Research 44, 3082-3094). Our current goals are 1) to determine the mechanisms of action of novel tissue specific and developmental regulatory elements in CFTR; and 2) to develop novel therapeutic approaches that target CFTR gene regulatory mechanisms.
Successful applicants for this CFF/NIH funded program will have a strong record of accomplishment as shown by publications as a graduate student and/or postdoc, be highly motivated and have a passion for human genetics/gene regulatory mechanism research. Expertise in one or more of the following areas is required: familiarity with use of public genome browsers and large data repositories; state of the art genomics technologies including ChIP-seq, RNA-seq, ATAC-seq, 4C-seq) and the use of relevant bioinformatic pipelines. CRISPR/Cas9 genetic manipulations.
Familiarity with general techniques of molecular biology and mammalian cell biology is essential. We are part of a vibrant and interactive research community at Case Western Reserve University and occupy excellent, modern laboratory space.
Please send an electronic letter of application, quoting the reference CWRU/AH2/2017, Curriculum Vitae and contact information of 3 referees to: firstname.lastname@example.org. Hiring is contingent upon eligibility to work in the United States.
WORKING CONDITIONS: Office and laboratory environment. May have exposure to hazards including animals, chemicals, blood-borne pathogens, lasers, and UV light in addition to DOT shipping/receiving of hazardous biological or infectious materials.
Case Western Reserve University is an Equal Opportunity Employer encouraging excellence through diversity. Qualified woman and minority candidates are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.