Postdoctoral Scholar, Department of Physiology & Biophysics

Postdoctoral scholars in membrane protein diseases

 

The Department of Physiology & Biophysics at Case Western Reserve University School of Medicine seeks two highly motivated postdoctoral scholars to conduct research in the laboratory of Dr. Tingwei Mu (https://physiology.case.edu/people/faculty/tingwei-mu/).

 

The Mu lab focuses on proteostasis maintenance of membrane proteins in the central nervous system. Membrane protein folding and misfolding is an emerging field in the medical science field. We use a combination of cell biological, biophysical, and electrophysiological approaches to study how the proteostasis network regulates the folding, degradation, assembly, trafficking and function of neuroreceptors in cells. Another research focus of the lab is the development of therapeutics that correct the misfolding of pathogenic ion channels, as a therapeutic strategy for the treatment of such protein conformational diseases.

 

The successful applicants will participate in projects on elucidating molecular basis of ion channel protein quality control. The qualified candidates will also be part of our drug discovery project for neurological diseases, such as epilepsy. The posted positions will be supported by a newly funded NIH RO1 grant. The successful candidates will be offered competitive salary and benefits packages, as well as considerable professional development opportunities.

 

One postdoc position is in the field of electrophysiology to perform patch clamping in mammalian cells, neurons, and brain slices. The other position is in the field of neuroscience to explore the folding and trafficking of neuroreceptors. The applicant must have a PhD and/or MD degree in biophysics, neuroscience, cell biology, pharmacology, or related field. Previous experience with endoplasmic reticulum biology, mouse genetic models, or neuroreceptorsrelated research is highly desired, but not required.

 

Interested individuals should send a cover letter, CV, and the names/phone numbers of three people who could provide letters of reference by email to tingwei.mu@case.edu. Review of applications will begin immediately and continue until the positions are filled.

 

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity.  Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

Case Western Reserve University provides reasonable accommodations to applicants with disabilities.  Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation.  Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.