Research Associate, Biochemistry

POSITION OBJECTIVE

Experienced Ph.D knowledgeable of the insulin molecule and prior synthetic studies of, and conduct research on novel insulin analogs. Ability to perform crystallization of insulin analogs. Skills and experience in chromatographic procedures including HPLC and LC-MS methods to verify the fidelity of synthesis. 

ESSENTIAL FUNCTIONS

  1. Implement protocols for the total chemical synthesis of insulin analogs

  2. Apply chemical protein synthesis to non-standard protein engineering.

  3. Apply enzyme-catalyzed methods of peptide-protein ligation.

  4. Mentorship of both undergraduate and graduate students at the bench.

  5. Apply experience with insulin molecules and prior synthetic studies of insulin analogs.

  6. Crystallize insulin analogs.

  7. Conduct chromatographic procedures, including HPLC and LC-MS methods to verify the fidelity of synthesis.

  8. Write papers and grant, poster or stage presentations for scientific meetings.

NONESSENTIAL FUNCTIONS

  1. Assist the research assistant in laboratory maintenance and safety records.

  2. Lab database organization.

  3. Maintain general organization of the laboratory together with the other member of the lab.

  4. Perform other duties as assigned.

CONTACTS

Department: Daily contact with the principal investigator, research associates and graduate students with the research group, in the course of conducting research activities; weekly contact with other departmental personnel or interdepartmental shared facilities personal o fascinate maintenance of laboratory facilities.

University: Occasional interactions with members from other departments

External: Occasional interactions with sales people for product inquires

Students: Train and supervise undergraduate and graduate students

SUPERVISORY RESPONSIBILITY

Supervise laboratory Research Assistant, postdoctoral scholars, graduate students and undergraduate students.

QUALIFICATIONS

Experience: List the basic (minimum) experience needed to be successful in the position. PhD in chemistry or biochemistry with at least two years post-doctoral experience, preferentially with prior experience in the total chemical synthesis of insulin analogs.

Education/Licensing: PhD in chemistry or biochemistry

REQUIRED KNOWLEDGE, SKILLS and ABILITIES

  1. Demonstrated expertise with the application of chemical protein synthesis to non-standard protein engineering.

  2. Experience with the insulin molecule and prior synthetic studies of insulin analogs.

  3. Experience with the crystallization of insulin analogs.

  4. Skills and experience are required with respect to chromatographic procedures, including HPLC and LC-MS methods to verify the fidelity of synthesis.

  5. Ability to effectively perform and train others in data mining and bioinformatics analysis. 

  6. Ability to write manuscripts for publication and grant.

  7. Excellent oral and written communication skills and interpersonal skills; must demonstrate the ability to effectively and professionally communicate and work with various individuals from a broad spectrum of disciplines, technical and educational backgrounds within the department, School and University, and with individuals outside the University.

  8. Strong organization abilities; ability to multi-task, prioritize and meet deadlines. Most demonstrate attention to detail and accuracy, time management skills, and follow-through.  

  9. Effectively train and work with team members, students, and staff.  Ability to be highly motivated, responsible, dependable and a self-starter.

  10. Ability to work under pressure, flexible to work in changing environment, and conform to shifting priorities, demands and timeline.

  11. Effective problem-solving skills; must demonstrate excellent analytical skills, sound judgment and good decision-making.

  12. Willingness and ability to update latest knowledge and share to team members.

WORKING CONDITIONS

The person will be working in a laboratory environment and be exposed to general chemicals; Chemical and Radiation Safety Training are required.  Required personal protective equipment includes a standard lab coat, gloves and safety glasses.  

LETTERS OF INTEREST

Application materials (a letter of interest and a CV) should be submitted electronically to Robert Kaderle, Business Manager at rxk141@case.edu 

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity.  Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

Case Western Reserve University provides reasonable accommodations to applicants with disabilities.  Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation.  Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.