Date: July 2021
Title: Research Associate
Department: Biomedical Engineering
Supervisor Name and Title: Mei Zhang, Ph.D; Assistant Professor of Biomedical Engineering and School of Medicine
The Research Associate will work independently to support research projects aimed to investigate cancer growth and metastasis influenced by a series of in-house developed immunomodulatory compounds. The Research Associate will play a lead role in the characterization of immune responses in response to the epigenetic/genetic immune modulatory compounds in vitro and in vivo, will work closely with the PI in the application of immune engineering techniques, and will assist the PI in supervision of lab operations and staff. The Research Associate will conduct animal research techniques.
- Utilize analytical, molecular, cellular, and mouse studies targeting in gain- and loss-of-immune function experiments and employ a wide array of cellular, molecular, animal model techniques.
- Present data at departmental seminars and scientific meetings, prepare manuscripts, and contribute preliminary data for grant proposals.
- Work closely with the PI in the application of immune engineering techniques to modify biomaterials
- Assist with supervision of students and trainees.
- Must demonstrate compliance with CWRU animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.
- Must demonstrate compassion for animals with CWRU facilities and dedication to the Animal Resource Center’s mission. Must handle animals with care and respect at all times.
- Must be able and willing to maintain a high standard of personal cleanliness and utilize protective gear to protect the health of animals.
- Perform other duties as assigned.
Department: PI, faculty, research staff and administrative staff
University: other departments as needed
External: Supply vendors, other institutions, funding agencies, etc.
Students: Undergraduate and graduate student employees
No direct supervisory responsibility. Oversee and train laboratory technicians/assistants and student trainees in experimental design and data analysis of a variety of projects.
Education: Ph.D. in Biochemistry, biology, immunology, physiology, or equivalent. A background in immune engineering and bioanalytical is highly preferred but not required.
Experience: Post-doctoral research experience of >3 years is required. Experience in modern techniques of analytical chemistry, molecular biology and mouse handling/experimentation is essential
The successful candidate must have strong analytical, oral and written communication skills
REQUIRED KNOWLEDGE, SKILLS and ABILITIES
- Expertise in mouse study as in vivo mouse genotyping and phenotyping
- In vitro cell culture techniques, Imaging-based cell biology techniques
- Molecular biology, biochemistry
- In vitro based immune cell phenotype and functional studies
- Experience in exposing laboratory animals with multiple drugs through IV, IP and oral administration.
- Experience in gene arrays and bioinformatics analysis is highly desirable - Experience with in-vivo immune characterization is strongly preferred - Proficiency in flow cytometry required - Experience in mouse surgery required – Experience in mouse and hemodynamic analyses required.
- Excellent oral and written communication skills and interpersonal skills; must demonstrate the ability to effectively and professionally communicate and work with various individuals within and external to the University.
- Strong organization skills; ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy, time management skills, and follow-through. Must be able to work under pressure and conform to shifting priorities, demands and timeline.
- Ability to lead, train, work with, and elicit cooperation from team members and staff.
- Ability to work effectively independently and collaboratively within a team. Must be highly motivated, responsible, dependable and a self-starter.
- Effective problem-solving skills; must demonstrate innovation and creativity, excellent analytical skills, sound judgment and good decision-making.
- Good computer skills, including database management.
Daily work will be conducted at Wolstein Research Building lab 2201 and 2202. Animal work will be conducted at ARC – Small Animal Imaging Center and Wolstein Building Animal Research Center. Labs are fully equipped with PPT for all the chemical, cellular and animal work to avoid contact with biohazard. No travel will be involved in this position. Occasional weekends are needed if cellular and animal work needs to be checked over the weekend.
Case's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals." This position, and all animal research personnel, are subject to internal compliance to SOM Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.
Send inquiries containing a cover letter, CV with list of publications and contact information for three references to Mei Zhang at email@example.com
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.