Working in close collaboration with a multi-investigator team consisting of clinicians and basic scientists within the CWRU GI Specialized Program of Research Excellence (SPORE), and CWRU P20 Disparities SPORE programs. The Research Associate will be an integral member of the Varadan Lab for Translational Systems Biology housed within the CWRU Comprehensive Cancer Center and will be working towards characterizing novel molecular drivers of Triple-Negative Breast Cancer and Esophageal Adenocarcinoma.
- Design and execute functional assays using in vitro model systems. Perform statistical analyses on experimental results, along with graphical presentation of data. (50%)
- Evaluate adequacy of techniques and provide feedback on experimental design. Collaborate with other members of the laboratory to achieve specific project goals. Direct the work of students when needed. (15%)
- Coordinate with the Athymic Animal & Preclinical Therapeutics shared resource facility at the Cancer Center who will conduct xenograft experiments using genetically-modified cancer cell lines generated in accordance with research goals. Obtain and analyze time-course data from xenograft core facility for therapy resistance/response studies. (15%)
- Write manuscripts for peer-reviewed journals and provide assistance with writing grant proposals (15%)
- Assist in collaborations with members of the Case Comprehensive Cancer Center, as well as those belonging to the University Hospitals, Cleveland Clinic, and other academic institutions. (3%)
- Perform other duties as assigned. (2%)
Department: Daily contact with supervisor; weekly laboratory meetings with entire laboratory.
University: Occasional contact with other departments to exchange information.
External: Monthly contact with collaborators within University Hospitals and/or Cleveland Clinic in the context of ongoing collaborations, exploring new molecular biology assays and/or collecting patient samples. Occasional contact with external collaborators and vendors to exchange information, evaluate and purchase equipment/supplies. Weekly contact for shipping and receiving supplies from other labs/companies to exchange information.
Students: Daily contact with student employees to maintain workflow.
Supervise and direct the work of students and other staff members; Ensure adoption of best practices in the laboratory by all students and staff members of the laboratory;
Experience: Candidates who are about to graduate in Spring 2019, or recent graduates with less than 3-years prior postdoctoral experience.
Education/Licensing: Doctoral degree in biomedical sciences with sub-specialties in any of Genetics, Cell Biology, Cancer Biology, Biochemistry, Molecular Biology, Pharmacology, Biotechnology or in other relevant fields
- Has a strong fundamental knowledge in cancer biology/genetics
- Some theoretical knowledge of basic bioinformatics and curated public cancer/genetic databases
- Hands-on expertise in molecular techniques routinely used in cancer research including but not limited to, cell culture, sequencing, generation of genetically modified cell lines, DNA/RNA/protein assessments, in vitro/in vivo assays etc.
- Prior expertise in mouse xenograft models is preferable
- Excellent oral and written communication skills
General laboratory environment. May have exposure to hazards. Employee will be exposed to blood-borne pathogens, chemicals, radiation, and lasers. Employee will need to wear appropriate protective equipment such as gloves, coat, and eyewear. Will work at bench performing experiments that requires standing and sitting and for long periods of time. Will perform some experiments in the animal room, standing in the laminar flow hood. Involves walking between different buildings in the University. May involve travel to meetings or conferences. Must be willing to adjust working hours according to the nature of ongoing experiments and work extended hours to finish the experiments.
Case's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals." This position, and all animal research personnel, are subject to internal compliance to SOM Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.
Interested candidates should email a cover letter, CV, and contact information for three references to Vinay Varadan, PhD at .
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office for Inclusion, Diversity and Equal Opportunity at 216.368.8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.