Research Associate - Case Comprehensive Cancer Center

Date: January 2022

Title: Research Associate

Department: Case Comprehensive Cancer Center

School: Medicine

Location: Wolstein Research Building

Supervisor Name and Title: William P. Schiemann, Professor

 

POSITION OBJECTIVE

Working in close collaboration with a multi-investigator team consisting of basic and translational scientists within the Schiemann Laboratory and the Case Comprehensive Cancer Center, the Research Associate will study the molecular mechanisms that enable breast cancers to establish and eventually emerge from metastatic dormancy. Our research is broad and includes interests in TGFbeta and cell signaling, cellular and metabolic plasticity related to CSCs, EMT programs, and telomere maintenance mechanisms. Additional interests are directed at understanding the molecular mechanisms underlying tumor heterogeneity, as well as interests in the epigenome, particularly chromatin remodeling and alternative splicing events driven by lncRNA. The Research Associate will be an integral member of the Schiemann Lab and pursue cutting-edge research in metastatic breast cancer, particularly those of the triple-negative subtype. The Research Associate may be required to perform animal research.

 

ESSENTIAL FUNCTIONS

  1. Design and execute functional assays using in vitro model systems. Perform statistical analyses on experimental results, along with graphical presentation of data. Oversee progress of the research and provide regular progress reports to the PI; and provide input and recommendation to principal investigator regarding significant developments in research projects. Ensure the PI is informed about the results of lab members, and ensure the PI’s experimental strategy is explored by lab members and through independent experiments by the Research Associate. (48%)
  2. Evaluate adequacy of techniques and provide feedback on experimental design. Collaborate with other members of the laboratory to achieve specific project goals. Direct the work of students when needed. (14%)
  3. Conduct in vivo analyses of breast cancer growth and metastasis using genetically-modified cancer cell lines generated in accordance with research goals. Obtain and analyze time-course data from xenograft core facility for therapy resistance/response studies. (14%) 
  4. Independently author research projects for peer-reviewed journals and provide assistance with writing grant proposals. Assemble data and make publication-quality figures from analyzed data. With the highest level of integrity and responsible conduct of research, participate in writing manuscripts as a first author and co-author for discoveries from research performed in the lab, together with the PI and other lab members. (14%)
  5. Mentor and train lab staff and graduate students; oversee research work and ensure pro jects are being completed according to the research plan. This will involve teaching other members of the lab techniques and scientific discovery methods, including students and post-docs. Assist and teach both established and new research techniques to other lab members to facilitate their experiments. (5%)

 

NONESSENTIAL FUNCTIONS

  1. Assist in collaborations with members of the Case Comprehensive Cancer Center, as well as those belonging to the University Hospitals, Cleveland Clinic, and other academic institutions. (3%)
  2. Perform other laboratory-related jobs/duties as assigned. (2%)

 

CONTACTS

Department: Daily contact with supervisor; weekly laboratory meetings with entire laboratory.

University: Occasional contact with other departments to exchange information.

External: Monthly contact with collaborators within University Hospitals and/or Cleveland Clinic in the context of ongoing collaborations, exploring new molecular biology assays and/or collecting patient samples. Occasional contact with external collaborators and vendors to exchange information, evaluate and purchase equipment/supplies. Weekly contact for shipping and receiving supplies from other labs/companies to exchange information.

Students: Daily contact with student employees to maintain workflow.

 

SUPERVISORY RESPONSIBILITY

Supervise and direct the work of students and other staff members; Ensure adoption of best practices in the laboratory by all students and staff members of the laboratory;

 

QUALIFICATIONS

Experience: No prior postdoctoral experience required.

Education/Licensing: Doctoral degree in biomedical sciences with sub-specialties in either Genetics, Cell Biology, Cancer Biology, Biochemistry, Molecular Biology, Pharmacology, Biotechnology or other relevant fields

 

REQUIRED SKILLS

  1. Demonstrated strong fundamental knowledge in cancer biology and cell signaling
  2. Hands-on expertise in molecular techniques routinely used in cancer research including but not limited to, cell culture, sequencing, generation of genetically modified cell lines, DNA/RNA/protein assessments, in vitro/in vivo assays, etc.
  3. Prior expertise in mouse xenograft models is preferable
  4. Excellent oral and written communication skills and interpersonal skills; must demonstrate the ability to effectively and professionally communicate and work with various individuals within and external to the University.
  5. Strong organization skills; ability to multi-task, prioritize and meet deadlines.  Must demonstrate attention to detail and accuracy, time management skills, and follow-through. Must be able to work under pressure and conform to shifting priorities, demands and timeline.   
  6. Ability to work effectively independently and collaboratively within a team.  Must be highly motivated, responsible, dependable and a self-starter.
  7. Effective problem-solving skills; must demonstrate innovation and creativity, excellent analytical skills, sound judgment and good decision-making. 
  8. Good computer skills, including database management. 
  9. Must demonstrate compliance with CWRU animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.
  10. Must demonstrate compassion for animals within CWRU facilities and dedication to the Animal Resource Center’s mission.  Must handle animals with care and respect at all times.
  11. Must be able and willing to maintain a high standard of personal cleanliness and utilize protective gear to protect the health the animals.

WORKING CONDITIONS

General laboratory environment. May have exposure to hazards. Employee will be exposed to blood-borne pathogens, chemicals, and lasers. Employee will need to wear appropriate protective equipment such as gloves, coat, and eyewear. Will work at bench performing experiments that requires standing and sitting for long periods of time. May perform some experiments in the animal room. Involves walking between different University buildings, as well as travel to meetings or conferences. Must be willing to adjust working hours according to the nature of ongoing experiments and work extended hours to finish the experiments.

Case's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals." This position, and all animal research personnel, are subject to internal compliance to SOM Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.

DIVERSITY STATEMENT

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity.  Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

COVID VACCINATION

Case Western Reserve University has implemented a COVID Vaccination policy requiring evidence of COVID-19 vaccination for all students, faculty and staff with an on-campus presence. Religious and medical exemptions may be provided in accordance with applicable federal and state laws. For more information, go to: https://case.edu/equity/covid-19-accommodations. Applicants may contact the Office of Equity at 216-368-3066 /equity@case.edu for information regarding religious or medical exemptions as an accommodation.

HOW TO APPLY

Send inquiries containing a cover letter and CV to Dr. Bill Schiemann  at william.schiemann@case.edu.

Strong internal candidate has been identified.