Research Associate - Department of Medicine




Date: 01/29/19

Title: Research Associate

Department: Medicine

School: Medicine

Location: MHMC

Supervisor Name and Title: Bingcheng Wang



I.       POSITION OBJECTIVE - The objective of this position is to efficiently perform laboratory investigations on the role of Eph receptor tyrosine kinase signaling in tumor initiation and malignant progression. The PI’s laboratory studies the molecular mechanisms that regulate fundamental biological processes such as cell migration, adhesion and proliferation, and applies the basic knowledge to tumor cell invasion and metastasis. Current focus of research is on Eph/ephrin signaling in the invasion of glioblastoma and metastasis of prostate cancer. A diverse array of modern technologies are being used in the PI’s laboratory to delineate the intricate molecular pathways initiated by Eph/ephrin systems, and to develop new therapeutic agents for the prevention and/or treatment of human cancer.


II.     ESSENTIAL FUNCTIONS – Research Associate to design and perform studies using genetically engineered mouse models (GEMM) as well as molecular, cellular, biochemical and approaches to dissect signaling pathways activated by Eph receptors in cancer. Key functions will include animal husbandry, breeding, genotyping, colony maintenance, and experiments. Tissue processing and analysis include routine histology, immunohistochemistry, frozen sections, tissues lysis and immunoblot. In addition, the applicant will participate in other related studies in cell and molecular biology, which include purification of plasmids, construction of expression vectors, immunoblotting, immunoprecipitation, RT-PCR, and immunofluorescence. Skill using computers to collect and analyze data will be important to have.


The research associate is expected to demonstrate significant mastery of scientific literature and certain independence in performing daily experiments. The ability to complete the projects in timely manner and write manuscript is essential for the position.


III.  NON-ESSENTIAL FUNCTIONS – Assistance with lab management responsibilities that require organizational and interpersonal skills. These include lab compliance with rules and regulation of the university and funding agencies, general laboratory/equipment maintenance, glassware washing and autoclaving, ordering supplies and co-ordinate lab activities.



         A.           Within department – Bing-Cheng Wang, Ph.D.

         B.           External to university – Coordinate collaborations with other labs.

C.              Students – Students and post-doctoral fellows in the lab.


V.    SUPERVISORY RESPONSIBILITIES - Teach techniques to new lab personnel. Supervise certain projects in the lab.



A.    Experience – PhD. Degree with minimum of 3 years of postdoctoral experience in a research laboratory is preferred.

B.     Previous publications in peer-reviewed journals.

C.    Technical skills – Experience and/or strong interests in mouse experiments, including maintenance of colonies of genetically engineered mice, tumor xenograft, small animal surgery, and carcinogenesis. Experience in histology, tissue staining, molecular biology, and protein biochemistry will help.


VII. WORKING CONDITIONS - Lab is approximately 1500 sq. ft., located in Rammelkamp Research Building on the MetroHealth Medical Center campus. Space will be shared with 6 to 8 other people. Major hazards include infrequent exposure to toxic agents.


Applicants should submit a curriculum vitae and cover letter to BingCheng Wang at


Case Western Reserve University provides reasonable accommodations to applicants with disabilities.  Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation.  Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.


In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity.  Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.