Title: Research Associate
Supervisor Name and Title: Douglas Rhee, M.D.; Chairman of Department of Ophthalmology for University Hospitals Cleveland Medical Center
I. STATEMENT OF RESEARCH AND SCIENTIFIC RESPONSIBILITIES
● A highly motivated and skilled researcher for vision research. Prior experience with techniques in molecular biology, extracellular matrix regulation, glycobiology, physiology, and/or small animal work is preferred. Interested candidate does not have to have prior vision research experience.
● Projects currently address the role of matricellular proteins in the regulation of human intraocular pressure (IOP), and the signaling pathway of the matricellular proteins in human trabecular meshwork where the outflow resistance occurs, thus cause IOP elevation. The lab is well-funded through the NIH and preparing for a second NIH award.
● The qualified candidate will utilize primary cell cultures (in vitro), transgenic mice (in vivo) and anterior chamber perfusion culture (ex vivo). Furthermore, the candidate will be required to perform the infection of viruses, treatment of small molecules, Western blot analysis, qPCR, mice breeding and genotyping, injection of viruses or drugs into the eyes of mice, culture of human anterior segment, immunofluorescent staining.
● As a search associate, he/she will present data at departmental seminars and scientific meetings, prepare manuscripts, and contribute preliminary data for grant proposals.
● Additional managerial experience such as preparation of animal protocols will be an asset and looked upon favorably.
II. TECHNICAL SKILLS
In vitro cell culture techniques, Imaging-based cell biology techniques
Expertise with transgenic mice
Molecular and cellular biology, Biochemistry
Perfused human anterior chamber culture (Ex vivo perfusion experiments)
Confocal and fluorescent microscopy
III. SUPERVISORY RESPONSIBILITIES
Supervise laboratory technicians/assistants and student trainees (undergraduate/medical) in experimental design and data analysis of a variety of projects.
IV. EDUCATION REQUIREMENTS
● Minimum qualifications include a Ph.D. in Ophthalmology, molecular/cellular biology, biochemistry, or equivalent. Prior post-doctoral research experience in ophthalmology (glaucoma) is highly
preferred, but not required. Experience in modern techniques of molecular biology and mouse handling/experimentation is essential.
● A background in Ophthalmology (primary open angle glaucoma) is highly preferred but not required. The successful candidate must have strong analytical, oral and written communication skills.
Send inquiries containing a cover letter, CV with list of publications and contact information for three references to douglas.rhee@UHhospitals.org.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.