The lab of Dr. Xiongwei Zhu at Department of Pathology is seeking a highly self-motivated Research Associate to study mitochondrial abnormalities in the area of neurodegeneration with a focus in Alzheimer disease and Parkinson disease. Research involves both cell-based systems and animal models.
1. Excellent bench work skills including confocal microscopy, electron microscopy, fluorescence, biochemical, and molecular techniques to probe mitochondrial form and function in slice culture, single cells, and isolated mitochondria preparations.
2. Must demonstrate the ability to thoughtfully design experiments
3. Must be highly organized and have efficient problem-solving capacity.
4. Needs to be self-motivated and show great willingness to gain expertise in new areas through literature research.
5. Will be required to manage collaborative projects, organize lab routines, write grants and manuscripts, train new lab members, coordinate with external and internal collaborators, and follow all the laboratory protocols, policies and guidelines.
1. Perform other duties such as coordinate and facilitate collaborative experiments with other investigators
Department: Daily contact with PI, post-docs and lab staff
University: Occasional contact with collaborating departments
External: Infrequent contact with vendors
Students: Frequent contact with students employees, ph.d. students
Supervise/Train Laboratory Research Assistant, postdoctoral scholars, graduate students and undergraduate students in conducting sample preparation, experimental design and data analysis of a variety of projects in the laboratory.
Experience: -Ph.D in molecular basis of learning and memory with more than ten years of postdoctoral and/or research scientist experience. Extensive expertise in neuroscience, molecular and cellular biology, autophagy, induced pluripotent stem cell culture, neuronal differentiation, proteomics, immune-electron microscopy and disease models to conduct research into the better understanding of pathogenic mechanisms of neurodegenerative diseases with an emphasis on dementia.
Multiple first-authored publications in reputable journals.
Education/Licensing: Ph.D. in Biology or other disciplines related to cell or molecular biology
1. Has knowledge of commonly-used concepts, practices, and procedures within the field of molecular biology.
2. Ability to perform routine molecular biology related techniques (histology techniques, immunocytochemistry, general cell and molecular biology techniques).
3. Ability to perform imaging (confocal microscopy, electron microscopy and fluorescence).
4. Induced pluripotent stem cell culture and neuronal differentiation.
5. Perform lenti-virus production and infection with primary or human iPSC differentiated neurons.
6. Ability to operate laboratory equipment.
7. Good organization skills.
8. Must demonstrate willingness to learn new techniques especially mouse-related techniques.
9. Must demonstrate excellent organization skills such as the ability to follow protocols, budget time effectively, and work on several projects simultaneously.
10. Excellent communication and team work skills required.
General laboratory environment, including work with exposure to hazardous chemicals, potential bloodborne pathogens, and radioactive materials. Occasional heavy lifting required up 25 to 49lbs. This position will work with animals and will deal with job hazards such as being around moving machinery, blood borne pathogens, chemicals, fumes, dust, infectious agents, and being present in restricted areas.
Case's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals." This position, and all animal research personnel, are subject to internal compliance to SOM Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.
Qualified candidates should submit their CV's to Xiongwei.Zhu@case.edu
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants required a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216.368.8877 to request a reasonable accommodation. Determines as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.