Research Associate, Department of Pathology

POSITION OBJECTIVE

This is a key position within the laboratory and will be responsible for planning and execution of experiments in close collaboration with the Principal Investigator. The lab is working closely together with other PI's in Pathology and the Cancer Center including collaborations with a multidisciplinary team of biologists, immunologists, pharmacologists, biomedical engineers and clinicians. The qualified candidate will prepare manuscripts and contribute preliminary data, background and significance and experimental design for grant proposals.

 

The work focuses on mechanisms regulating anti-tumor immune response and the predictive/ prognostic value of the tumor immune microenvironment, with particular emphasis on breast cancer and gynecologic malignancies. The work will involve using experimental techniques ranging from basic molecular biology, immunology, biochemistry to cell culture and animal studies, and molecular analysis of tumor tissue samples. The candidate should be able to work independently. He/She should be competent to read the literature, assist with designing and planning of projects and oversee the collaborations, manage animal models and to carry out research on the assigned project.  Should contribute to apply/secure funding for the lab.

 

ESSENTIAL FUNCTIONS

1.    Design, plan and carry out experiments in collaboration with PI. Provide assistance and oversight of staff, post-doctoral scholars and graduate students/fellows ensuring projects are being completed according to the research plan. Advise/Assist in developing improved techniques, project methods, or procedures.

2.    Oversee general lab operations including inventory, lab organization and maintain certain equipment/facilities. Must demonstrate compliance with policies, procedures and regulations of the Animal Resource Center, IACUC, Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines for which essential training will be provided.

3.    Develop, adapt, and implement new research techniques and protocols.

4.    Analyze, interpret, summarize and record results; provide high level analysis to PI.

5.    Preparation of grant proposals with the goal of securing lab funding.

6.    Lead writing of publications and presentations as author or co-author.

7.    Plan and execute research in collaboration with other investigators on and off campus.

8.    Perform/supervise rodent studies including genotyping, maintaining an accurate animal database, tumor inoculation (s.c., orthotopic sites) and drug administration (oral, i.p., i.v.).

9.    Develop and maintain an external reputation through activities such as publishing in high quality peer-reviewed journals, refereeing and conference presentations.

 

NONESSENTIAL FUNCTIONS

1.    Assist to manage lab wastes, organize lab inventory and take care of lab safety.

2.    Perform other duties as assigned.

 

CONTACTS

Department: Admin staff - Occasional

University: Environment health and safety, Animal Resource Center - Occasional

External: Collaborators - Occasional

Students: Graduate and undergraduate - Occasional

 

SUPERVISORY RESPONSIBILITY

Train and oversee rotating students/fellows, provide essential technical advice at bench and take part in discussions with them.

 

QUALIFICATIONS

Experience: >2 years of post-graduate research experience (after PhD)

Education: PhD in Life Sciences with experience in Molecular and Cell Biology, Cancer Biology and Biochemistry (experience in immunology or tumor immunology beneficial)

 

 

REQUIRED SKILLS

1.    Ability to work effectively independently strictly following directions and protocols, and to work well collaboratively within a team. Must be highly motivated, responsible and dependable.

2.    Good organization skills; ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy, good time management, ability to work on several projects simultaneously and follow-through on assigned tasks.

3.    Good problem-solving skills; must demonstrate good analytical skills, sound judgment and good decision-making.

4.    Good interpersonal skills; ability to work and communicate with various individuals within and external to the University.

5.    Must demonstrate flexibility and ability to work under pressure, must be able and willing to conform to shifting priorities, demands and timelines.

6.    Effective oral and written communication skills; Must be able to effectively communicate with the PI/supervisor as well as other lab members.

7.    Ability to work with sensitive information and maintain confidentiality, and to consent patients for clinical-translational studies.

8.    Knowledge of commonly-used concepts, practices, and procedures in biomedical and cancer research, molecular biology, and (tumor) immunology.

9.    Familiarity and compliance with policies and procedures of lab and chemical safety and laboratory animal handling and welfare.

10.  Ability to organize, maintain and prepare accurate records.

11.  Ability to rely on and follow instructions and pre-established guidelines to perform the functions of the job.

12.  Ability to operate laboratory equipment and learn to operate new instruments.

13.  Knowledge in Microsoft Office, database applications, and with internet navigation.

14. Willingness to learn new techniques, procedures, processes, and software programs as needed.

 

Qualified applicants should submit CV's to Stefanie.Avril@case.edu

 

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants required a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216.368.8877 to request a reasonable accommodation. Determines as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.