Date: June 23, 2020 Title: Research Associate
Department: Division of Cancer Biology, Department of Medicine School: School of Medicine
Location: MetroHealth Medical Center
Supervisor Name and Title: BingCheng Wang. PhD
The Wang laboratory investigates the basic molecular mechanisms and strategies for therapeutic interventions of tumor metastasis that account for 90% of cancer-related deaths worldwide. We focus on the roles of Eph receptor tyrosine kinases (RTK) and their membrane-anchored Ephrin ligands in oncogenesis. Our pioneering studies have revealed novel roles of EphA2 in both the initiation and progression of several types of human malignant diseases including prostate cancer, brain tumor and skin cancer. Current projects include 1) genetically engineered mouse models (GEMM) to study tumor etiology and progress progression toward invasion and metastasis, 2) structure and function characterization of Eph receptor tyrosine kinase in regulating malignant behaviors in vitro and in vivo, 3) relationship between cancer stem cell properties and malignant progression, 4) discovery and optimization of novel small molecule drugs targeting molecular pathways that drive tumor invasion and metastasis, and 5) regulation of tumor immune surveillance by Eph/ephrin system, and how it can be exploited for cancer immunotherapy. Multidisciplinary approaches are utilized including in vitro cell culture, GEMMs, virtual screening coupled with medicinal chemistry, fluorescence correlation coefficient spectrometry, epithelial organoids isolation and culture, as well as patient-derived xenografts (PDX). Over the years, the lab has made multiple seminal contributions to our current understanding of Eph receptor tyrosine kinases in tumor initiation, local invasion and distal metastasis that are published in journals such as Cancer Cell, Nature Cell Biol, Science Signaling, Cancer Res, and JCB.
- Use GEMM models to investigate the dual roles of EphA2 in tumor initiation and progression.
- Characterize the molecular and cellular mechanisms of Eph/ephrin regulation of oncogenesis using GEMM, cell culture in vitro, and human specimens.
- Prepare manuscript in a timely fashion.
- Provide preliminary results for grant application.
- Effectively communicate research at lab meetings as well as at local, national and international meetings.
- Work with other members of the lab to keep the lab clean, organized and highly functional state.
- Provide voluntary support for the lab when needed.
- Perform other duties as assigned.
CONTACTS This section is important in rating the position, so please give it thought and consideration when developing the position description. Indicate who the incumbent will have contact with (i.e., department staff, students, potential donors), the frequency (i.e., infrequent (up to 5%), occasional (6- 15%), moderate (16-30%), regular (31-45%), frequent (46-65%), and continuous (66+%) and for what purpose (i.e., provide information, resolve complaints, solicit donations).
Department: Bing-Cheng Wang (Frequent)
University: Engage and effectively utilize with Shared Resources at the Case Comprehensive Cancer and other local research facilities (moderate)
External: Negotiate and order special reagents and supplies through external suppliers in coordination with the PI and institutional purchasers (Occasional).
Students and postdocs: Ryan Lingerak, Roger Xiaojun Shi, and Ji Zheng (regular)
Undergraduate, medical and graduate students, and residents
Experience: Biomedical researcher with experience in animal models, cell culture and molecular biology.
Education/Licensing: Creative and motivated cancer biologists with Ph.D., M.D., or both degrees, and proven record of research productivity are welcome to apply.
Working experience using Transgenic/Knockout Mouse Models is valuable; knowledge of immunology, Cell Signaling, Stem Cells, Bioinformatics is a plus.
MetroHealth Medical Center is closely affiliated with Case Western Reserve University School of Medicine. Throughout its 1806 years of history, it is well known nationally and internationally for its research excellence with Nobel and Lasker awards winners among its alumni. Recently cancer research has been identified as a new focus of strategic research priorities with rapidly expanding programs in breast, cancer, brain tumor, and liver cancer research. The well-equipped and well-funded lab has all the advanced instrumentation and experimental system to perform cutting edge cancer research. Limited number of hazardous materials common in most cancer research labs are also present. Occasional travelling to national and international meetings and collaborating labs is required.
Competitive salary and generous benefit package will be provided for qualified candidates. Case Western Reserve University is an equal opportunity employer. Please send your C.V. and contact information for three references to: Dr. Bing C. Wang, email: email@example.com.