Date: December 2019
Title: Research Associate
Department: Medicine / Institute for Transformative Molecular Medicine
Location: 4th floor - Wolstein Research Building, 2103 Cornell Road
Supervisor Name and Title: Jonathan Stamler, MD., Professor of Medicine and Biochemistry, Robert S. and Sylvia K. Reitman Family Foundation Distinguished Chair in Cardiovascular Innovation; Director, Institute for Transformative Molecular Medicine; and President, Harrington Discovery Institute
The laboratory of Jonathan Stamler at the Institute for Transformative Molecular Medicine at Case Western Reserve University and the Harrington Discovery Institute, University Hospitals Cleveland Medical Center in Cleveland, Ohio is seeking an ambitious and energetic post-doctoral fellow. The Stamler lab is a dynamic environment engaged in a wide array of basic and translational studies (see Cell 2019 176:1014-1025; Nature 2019 565:96-100; Mol Cell 2018 70:473-487; Mol Cell 2018 69:451-464) seeking to understand protein S-nitrosylation as an enzymatically-regulated post-translational modification that alters protein functions broadly in physiology and in pathophysiology/disease, and to manipulate this for therapeutic benefit.
This Research Associate will examine the role of protein-S-nitrosylation in regulating G protein-coupled receptor signaling pathways, particularly in the lung (asthma) and heart (heart failure). Desired expertise includes experience with model cell systems and in vivo physiology of lung/heart, GPCR signaling pathway analysis, and biochemical/enzymology/proteomic methods.
- Develop experimental design for research projects, carry out experiments at the bench and perform day-to-day data analysis. Amend research direction as necessary based on results and developments in the field.
- Develop new protocols and techniques as needed.
- Present data at laboratory and institutional seminars, and at scientific meetings.
- Prepare initial drafts of scientific manuscripts, including figures and other data, for publication in high-impact peer-reviewed journals. Contribute to preliminary data, background, significance and experimental design sections of grant proposals.
- Maintain meticulous records of experiments.
- Maintain all training certifications required to participate in the biomedical research.
- Operate and maintain laboratory equipment and instruments.
- Train undergraduate and graduate students as requested.
- General laboratory maintenance.
- Perform other duties as assigned.
- Department: Contact with supervisor to plan and discuss research. Contact with staff, students, and faculty within the ITMM and the Department to exchange ideas and expertise.
- University: Moderate contact outside the department but within the University to fulfill research objectives
- External: Occasional contact with researchers from other institutions to exchange ideas and research materials
- Students: Contact with undergraduates and graduate students with varying frequency
- Supervise/train research assistants and student trainees in their assigned duties as needed.
- Education/Licensing: A Ph.D. in biochemistry, neurobiology, pharmacology or physiology
- Experience: Prior research experience with mouse models of aging and neurodegeneration, brain microvasculature/neurovascular unit, and in vivo brain imaging is strongly preferred.
- The ability to work independently as well as collaboratively with a team
- Strong analytical skills
- Strong organizational skills and attention to detail and accuracy
- Ability to effectively manage time, multi-task, and prioritize
Please e-mail a cover letter describing past training, research interests and career goals, along with a detailed CV and contact information for three references to Dr. Jonathan Stamler, c/o Laura Dillon at firstname.lastname@example.org. Please indicate that you are applying for position # 429.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.