Research Associate (Laboratory Research) #228 - Pathology

 

Date: December 2021

Title: Research Associate (Laboratory Research), 228

Department: Pathology

School: Medicine

Location: Wolstein Research Building

Supervisor Name and Title: Param Ramakrishnan, Associate Professor

 

POSITION OBJECTIVE

This is a key position within the lab and will be responsible for planning and execution of experiments in close collaboration with the Principal Investigator. The lab is working closely together with other PI's in Pathology and school of medicine including collaborations with a multidisciplinary team of biologists, chemists, physicists and clinicians. The qualified candidate will lead the experiments at the bench using cellular systems, animal models and patient samples, prepare manuscripts and contribute preliminary data, background and significance and experimental design for grant proposals.

The lab focuses on novel mechanisms regulating NF-kB transcription family pathway, role of adaptor proteins such as Sam68 and posttranslational modifications in conditions such as inflammatory bowel disease, autoimmune diabetes and cancer. 

The key focus of this position is inflammatory bowel disease. The work will involve using experimental techniques ranging from basic molecular biology, immunology, biochemistry, cell culture, patient samples and animal studies.  The candidate will work independently. He/she should be competent to read the literature, come up with experimental ideas and protocols, assist with designing and planning of projects and oversee other personnel to carry out research on the assigned project.  Expected to apply/secure training fellowships. 

 

ESSENTIAL FUNCTIONS 

  1. Conduct experiments to supply scientific data and information as part of a larger project. Studies involve but are not limited to techniques including Western blotting, immunoprecipitation, ELISA, DNA and RNA isolation, PCR, RT-PCR, cloning, protein expression, study of patient samples, in vivo studies using animals including IBD models, 3D organoid cultures, flow cytometry, histology, etc.) Analyze data and provide findings and recommendations to the PI based on analysis. Perform/supervise rodent husbandry including breeding, genotyping and maintain an accurate animal database.  (37.5%)
  2. Plan and execute experiments for research projects designed by the principal investigator and may design experiments independently and in collaboration with the PI. Provide assistance and oversight of staff, post-doctoral scholars, graduate, Masters and undergraduate students ensuring projects are being completed according to the research plan. Advise/Assist in developing improved techniques, project methods, or procedures. (17.5%)
  3. Present data and findings at laboratory meetings and scientific meetings, seminars, etc. Prepare manuscripts, and conduct experiments and contribute preliminary data for grant proposals.  (12.5%)
  4. Independently author research projects. Assemble data and make publication-quality figures from analyzed data. With the highest level of integrity and responsible conduct of research, participate in writing manuscripts as a first author and co-author for discoveries from research performed in the lab, together with the PI and other lab members. Assist in manuscript preparation.  (10.0%)
  5. Assist with and contribute to experiments performed by other lab members, ensuring adequate resources, assisting with experimental design and analysis. Oversee progress of the research projects and provide regular progress reports to the PI; and provide input and recommendation to principal investigator regarding significant developments in research projects. (5.0%)
  6. Assist the PI in and independently develop new techniques and protocols. Train lab members on new techniques.  (5%)
  7. May supervise research assistants and technicians. Supervise the research and technical work performed by other lab members, ensuring proper lab procedures are followed, and their safety, and ensuring adequate resources are provided for lab work. Coordinate trainings for lab members with the EHS, ARC, radioactive and biosafety trainings and others, as needed.  (5%)
  8. Operate laboratory equipment and maintain their smooth functioning, including inventory, lab organization and maintain certain equipment/facilities. Assist other lab members with general lab maintenance and help oversee and maintain inventory of scientific reagents. Oversee general lab operations including inventory, lab organization and maintain certain equipment/facilities. (5%)
  9. Assess, update, and develop new standard operating procedures (SOPs) for the lab. (2.5%)

 

NONESSENTIAL FUNCTIONS

  1. Perform other duties as assigned. (<1%)

 

CONTACTS 

Department: Frequent contact with PI and lab members, may work with other faculty for collaboration of research projects, contact with administrative staff as needed

University: Regular/Occasional contact with other labs for collaboration, Regular/Occasional contact with the Animal Resource Center, Contact with other departments as needed

External: Supply vendors, other institutions, funding agencies, etc. as needed

Students: Undergraduate and graduate student employees working in the lab

 

SUPERVISORY RESPONSIBILITY

No direct supervisory responsibilities. Will train and provide oversight to lab staff and students as instructed by the PI.

 

QUALIFICATIONS 

Experience: Minimum of 1 to 5 years of related postdoctoral experience required. Experience in preferred field(s) of study preferred with lead author publications.

Education: PhD in life sciences, MD, or DO 

 

REQUIRED KNOWLEDGE, SKILLS and ABILITIES 

 

  1. Ability to work well with others and to work independently strictly following directions and protocols.
  2. Ability to collect and analyze data with attention to detail and do multiple tasks simultaneously.
  3. Effective oral and written communication skills.  Must be able to effectively communicate with the PI/supervisor as well as other lab members.
  4. Good interpersonal skills; ability to work and communicate with various individuals within and external to the University.  
  5. Good organization skills; ability to multi-task, prioritize and meet deadlines.  Must demonstrate attention to detail and accuracy and follow-through on assigned tasks.
  6. Ability to work effectively independently and collaboratively within a team.
  7. Ability to work with sensitive information and maintain confidentiality. 
  8. Good problem-solving skills; must demonstrate good analytical skills, sound judgment and good decision-making. 
  9. Ability to rely on and follow instructions and pre-established guidelines to perform the functions of the job.
  10. Ability to operate laboratory equipment and learn to operate new instruments
  11. Familiarity with policies and procedures of lab and chemical safety
  12. Knowledge in Microsoft Office, database applications, and with internet navigation. 
  13. Willingness to learn new techniques, procedures, processes, and software programs as needed.
  14. Ability to organize, maintain and prepare accurate records
  15. Must demonstrate flexibility and ability to work under pressure; must be able and willing to conform to shifting priorities, demands and timeline. 
  16. Must be willing to adjust working hours according to the nature of ongoing experiments and many times work extended hours to finish the experiments. Working on weekends and holidays are required depending on the ongoing experiments and need to accelerate data generation and collections
  17. Excellent analytical skills; ability to formulate findings and recommendations from the analysis. 
  18. Strong organization skills; ability to multi-task, prioritize, and meet deadlines.  Must demonstrate attention to detail and accuracy, time management skills, and follow-through. Must be able to work under pressure and conform to shifting priorities, demands, and timeline.    
  19. Effective leadership skills; ability to lead, train, work with, and elicit cooperation from team members and staff.  
  20. Ability to work effectively independently and collaboratively within a team.  Must be highly motivated, responsible, dependable, and a self-starter. 
  21. Effective problem-solving skills; must demonstrate innovation and creativity, sound judgment, and good decision-making.  
  22. Good computer skills, including database management. Ability to learn new programs as needed. 
  23. Knowledge on bioinformatics, DNA analysis, microarray and RNA seq data mining, MS word, excel, powerpoint, prism, photoshop, etc are essential.
  24. Must demonstrate compliance with CWRU animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.
  25. Must demonstrate compassion for animals within CWRU facilities and dedication to the Animal Resource Center’s mission.  Must handle animals with care and respect at all times.
  26. Must be able and willing to maintain a high standard of personal cleanliness and utilize protective gear to protect the health the animals.

 

WORKING CONDITIONS 

Working indoors at workbench, cell culture hood, instrument rooms, both sitting and standing for long time. Working with animals, exposures to regular biohazards (no select agents at present). May include lifting weights that one person can handle or join others for lab organization and moving instruments. Position may include occasional travel for meetings based on securing travel awards, travel between local institutes including CCF, VA, UH and Metro Health. Necessary flexibility is needed to work in early mornings, late evenings, and weekends. 

 

Case's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals."  This position, and all animal research personnel, are subject to internal compliance to SOM Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.

 

DIVERSITY STATEMENT

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity.  Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

 

REASONABLE ACCOMMODATIONS

Case Western Reserve University provides reasonable accommodations to applicants with disabilities.  Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity at 216-368-3066 to request a reasonable accommodation.  Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

 

COVID VACCINATION

Case Western Reserve University has implemented a COVID Vaccination policy requiring evidence of COVID-19 vaccination for all students, faculty and staff with an on-campus presence. Religious and medical exemptions may be provided in accordance with applicable federal and state laws. For more information go to: https://case.edu/equity/covid-19-accommodations. Applicants may contact the Office of Equity at 216-368-3066 /equity@case.edu for information regarding religious or medical exemptions as an accommodation.

 

HOW TO APPLY

Send inquiries containing a cover letter, CV with a list of publications and contact information for three references to references to Dr. Param Ramakrishnan at pxr150@case.edu