Research Associate (Laboratory Research), #229 - Pathology

Date: April 2021

Title: Research Associate (Laboratory Research), #229

Department: Pathology

School:  Medicine

Location: Wolstein Research Building, 2103 Cornell Rd, Room 3-404, Cleveland, OH 44106

Supervisor Name and Title: David Wald, Associate Professor

 

 

POSITION OBJECTIVE

The Research Associate (RA) at Case Western Reserve University will be responsible for designing

and conducting cancer research studies to develop strategies for NK cell therapy.  The RA will be involved in the use of multiple cancer model systems including leukemia and colon cancer. The RA will conduct experimental work using cell and animal models and analyze results. The RA will be expected to work in a highly independent fashion to design and conduct research experiments, analyze data, prepare manuscripts/grant applications and to present research results.

 

In addition to these scientific responsibilities, the RA will also work in collaboration with faculty members to write manuscripts, assist with grant applications, present results at meetings, and supervise and train other lab members on research procedures.

 

ESSENTIAL FUNCTIONS

  1. Plan and execute experiments for research projects designed by the principal investigator and may design experiments independently and in collaboration with the PI. Assist with and coordinate experiments performed by other lab members, ensuring adequate resources, assisting with experimental design and analysis. Oversee progress of the research projects and provide regular progress reports to the PI; and provide input and recommendation to principal investigator regarding significant developments in research projects. Ensure the PI is informed about the results of lab members, and ensure the PI’s experimental strategy is explored by lab members and through independent experiments by the Research Associate. Work with the PI to conduct experimental work related to cancer biology. In particular, this will involve testing of therapeutics in colon cancer cell and animal based systems and performing assays including RNA sequencing, cytokine analysis and flow cytometry. (26%)
  2. Conduct experiments to supply scientific information as part of a larger project. Studies involve but are not limited to analysis of large RNA sequencing datasets. Develop new research techniques related to spatial transcriptomics and single cell sequencing. Maintain accurate records of data and provide findings and recommendations to the PI based on analysis. (10%)
  3. Present data and findings at laboratory meetings and scientific meetings, seminars, etc. Prepare manuscripts, and contribute preliminary data for grant proposals. (10%)
  4. Assist the PI in and independently develop new techniques and protocols. Train lab members on new techniques. (10%)
  5. Mentor and train lab staff and graduate students; oversee research work and ensure pro jects are being completed according to the research plan. This will involve teaching other members of the lab techniques and scientific discovery methods, including students and post-docs. Assist and teach both established and new research techniques to other lab members to facilitate their experiments. Coordinate trainings for lab members with the EHS and others, as needed. (10%)
  6. Independently author research projects. Assemble data and make publication-quality figures from analyzed data. With the highest level of integrity and responsible conduct of research, participate in writing manuscripts as a first author and co-author for discoveries from research performed in the lab, together with the PI and other lab members. (10%)
  7. Assess, update, and develop new standard operating procedures (SOPs) for the lab. (6%)
  8. May supervise research assistants and technicians. Supervise the research and technical work performed by other lab members, ensuring proper lab procedures are followed, and their safety, and ensuring adequate resources are provided for lab work. (6%)
  9. Analyze, interpret, summarize, and compile data to present experimental results at meetings. Attend local seminars and present at local and national meetings. (6%)
  10. Manage project timeline and budget. (6%)

 

NONESSENTIAL FUNCTIONS

  1. Perform other duties as assigned (<1%)

 

CONTACTS

Department: The candidate will have regular contact with the Pathology Administration and other laboratories in the department

University: The candidate will have regular contact with the Cancer Center Administration, IACUC office, ARC office, DOES office and other laboratories in the university focused on cancer research.

External: No contact with vendors to exchange information.

Students: The candidate will have regular contact with high school, undergraduate and graduate students.

 

SUPERVISORY RESPONSIBILITY

No direct supervisory responsibilities. The candidate will be responsible for supervising and training junior laboratory members including high school students, undergraduate students, and graduate students. 

 

QUALIFICATIONS

Education/Licensing: PhD in biomedical sciences or a related field

Experience: At least 3 years of experience in Cancer Research and multiple first author publications.

 

REQUIRED SKILLS

  1. Advanced skills and a deep understanding of concepts, practices, and procedures within the field of cancer biology. 
  2. Demonstrated expertise in mouse handling.
  3. Professional and effective oral and written communication skills; and good interpersonal skills with the ability to work and communicate with various individuals within and external to the University.  Must be able to clearly relay information to the PI and other researchers and prepare written documents for grant submissions, manuscripts, publications, etc. as needed.
  4. Strong organization skills; ability to multi-task, prioritize and meet deadlines.  Must demonstrate attention to detail and accuracy, time management skills, and follow-through.  
  5. Effective management skills; ability to lead, train, work with, and elicit cooperation from team members and staff. 
  6. Ability to work effectively independently and collaboratively within a team.  Must be highly motivated, responsible, dependable and a self-starter.  Must demonstrate a strong desire to learn and to advance research.
  7. Effective problem-solving skills; must demonstrate excellent analytical skills, sound judgment and good decision-making. 
  8. Must demonstrate flexibility and ability to work under pressure; must be able and willing to conform to shifting priorities, demands and timeline. 
  9. Willingness to follow protocols and provide suggestions to the PI. 
  10. Ability to operate laboratory equipment. 
  11. Good computer skills; must demonstrate proficiency in Microsoft Office and data management.
  12. Must demonstrate compliance with university animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other appliable regulatory guidelines.
  13. Must demonstrate compassion for animals within university facilities and dedication to the Animal Resource Center’s mission. Must handle animals with care and respect at all times.
  14. Must be able and willing to learn new techniques, procedures, processes, and computer gear to protect the health of the animals.
  15. Previous experience working with animals is preferred.

 

WORKING CONDITIONS

General laboratory environment. May have exposure to hazards, such as chemicals, fumes, dust, animals. Personal protective equipment required, such as gloves, safety shoes, laboratory coat. May lift up to 24 lbs.

Case Western Reserve University’s animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the “Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Human Care and use of Laboratory Animals.” This position, and all animal research personnel, are subject to internal compliance to SOM Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations, and other applicable regulatory guidelines.

 

DIVERSITY STATEMENT

Case Western Reserve University strives to maintain a diverse and inclusive work environment and is committed to Equal Opportunity and Diversity. All applicants are protected under Federal law from discrimination based on race, color, religion, sex, national origin, disability, age, and genetics.

 

REASONABLE ACCOMODATIONS

Case Western Reserve provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Equity by phone at 216.368.3066 or by email at equity@case.edu. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

 

COVID VACCINATION

Case Western Reserve University has implemented a COVID Vaccination policy requiring evidence of COVID-19 vaccination for all students, faculty and staff with an on-campus presence. Religious and medical exemptions may be provided in accordance with applicable federal and state laws. For more information go to: https://case.edu/equity/covid-19-accommodations. Applicants may contact the Office of Equity at 216-368-3066 /equity@case.edu for information regarding religious or medical exemptions as an accommodation.

 

HOW TO APPLY

Send inquiries containing a cover letter (CV) with a list of publications and contact information with 3 references to David Wald at dnw@case.edu