Research Associate (Laboratory Research) - Biomedical Engineering

Date: October 2021

Title: Research Associate (Laboratory Research)

Department: Biomedical Engineering

School: Medicine

Location: Sears Tower

Supervisor Name and Title: Satish Viswanath/Pallavi Tiwari, PhD; Assistant Professors, SOM

POSITION OBJECTIVE

The BrIC and INVent labs focus on development of novel computational imaging, radiomics, radiogenomics, and machine learning solutions for applications in disease diagnosis, prognosis, therapeutic response, and outcome prediction for multiple cancers and diseases. The Research Associate will execute research projects with the aim of applying novel machine learning and deep learning tools in radiographic imaging of diseases towards detection, diagnosis, prognosis as well as treatment response. Under the guidance of the PIs, the Research Associate is expected to work independently, design and plan projects, oversee collaborations, supervise students, manage animal models, and carry out research activities of an assigned project through completion. The Research Associate will utilize expert annotations, segmentations, identifications of regions of interest, provide input in hand-crafted feature learning approaches, as well as quality control of images as well as algorithm validation and development. The Research Associate will keep the PIs informed of progress of research projects and provide recommendations on experimental design. The Research Associate will also present data and findings at lab and scientific meetings, seminars, etc., prepare manuscripts, and contribute preliminary data for grant proposals. 

 

ESSENTIAL FUNCTIONS

  1. Plan and execute experiments for research projects designed by the principal investigator and may design experiments independently and in collaboration with the PI. Assist with and coordinate experiments performed by other lab members, ensuring adequate resources, assisting with experimental design and analysis. Oversee progress of the research projects and provide regular progress reports to the PI; and provide input and recommendation to principal investigator regarding significant developments in research projects. Ensure the PI is informed about the results of lab members, and ensure the PI’s experimental strategy is explored by lab members and through independent experiments by the Research Associate. (50%)
  2. Conduct experiments to supply scientific information as part of a larger project. Studies involve but are not limited to analysis of radiographic images (MRI, CT, X-Ray, PET) towards radiomics projects in the group gaining familiarly with the organization of the High-Performance Cluster (HPC) servers and files. Maintain accurate records of data and provide findings and recommendations to the PI based on analysis.
  3. Assist the PI in and independently develop new techniques and protocols. Train lab members on new techniques. 
  4. Mentor and train lab staff and graduate students; oversee research work and ensure projects are being completed according to the research plan. This will involve teaching other members of the lab techniques and scientific discovery methods, including students and post-docs. Assist and teach both established and new research techniques to other lab members to facilitate their experiments. Coordinate trainings for lab members with the EHS and others, as needed.
  5. Present data and findings at laboratory meetings and scientific meetings, seminars, etc. Prepare manuscripts, and contribute preliminary data for grant proposals. 
  6. Independently author research projects. Assemble data and make publication-quality figures from analyzed data. With the highest level of integrity and responsible conduct of research, participate in writing manuscripts as a first author and co-author for discoveries from research performed in the lab, together with the PI and other lab members.
  7. Assess, update, and develop new standard operating procedures (SOPs) for the lab. Quality control the images for AI analysis using approaches developed by the lab as well as using his/her expertise in detecting artifacts, image quality. Submit IRB applications for human subjects-related research protocols and Data Use Agreement (DUA) /Material Transfer Agreement (MTA) forms through the CWRU Office of Research Administration.
  8. May supervise research assistants and technicians. Supervise the research and technical work performed by other lab members, ensuring proper lab procedures are followed, and their safety, and ensuring adequate resources are provided for lab work.
  9. Operate laboratory equipment such as PACS tools to access radiographic images. Play a central role in facilitating acquiring these images from the clinical centers including leading efforts for deidentification and modality determination. Assist other lab members with general lab maintenance and help oversee and maintain inventory of scientific reagents.
  10. Participate in strategy and planning meetings with faculty advisors and the research team to ascertain needs and actions associated with the research projects and the associated research goals. Must understand the domain of the research and be acutely aware of the research projects and the research goals.

 

NONESSENTIAL FUNCTIONS

  1. Perform other duties as assigned.

 

CONTACTS

Department: Frequent contact with PI and lab members, may work with other faculty for collaboration of research projects, contact with administrative staff as needed

University: Regular/Occasional contact with other labs for collaboration, Regular/Occasional contact with the Animal Resource Center, Contact with other departments as needed        

External: Supply vendors, other institutions, funding agencies, etc. as needed

Students: Undergraduate and graduate student employees working in the lab

 

SUPERVISORY RESPONSIBILITY

No direct supervisory responsibilities. Will train and provide oversight to lab staff and students.

 

QUALIFICATIONS

Experience: Minimum of 1 to 5 years of related postdoctoral experience required. Experience in preferred field(s) of study preferred.

Education/Licensing: PhD, MD, or other terminal degree in medicine, radiology, pathology, or similar. 

 

REQUIRED KNOWLEDGE, SKILLS and ABILITIES

  1. Familiarity with medical databases (e.g. REDCap), image databases (PACS tools), EHR databases (e.g. EPIC). Extensive expert level domain knowledge in medicine/radiology/imaging techniques. Familiarity with image scanners and scanning protocols.
  2. Understanding of image analysis tools such as 3D Slicer, MATLAB, etc.
  3. Excellent analytical skills; ability to formulate findings and recommendations from the analysis.
  4. Excellent oral and written communication skills and interpersonal skills; must demonstrate the ability to effectively and professionally communicate and work with various individuals within and external to the University.
  5. Strong organization skills; ability to multi-task, prioritize, and meet deadlines.  Must demonstrate attention to detail and accuracy, time management skills, and follow-through. Must be able to work under pressure and conform to shifting priorities, demands, and timeline.    
  6. Effective leadership skills; ability to lead, train, work with, and elicit cooperation from team members and staff. 
  7. Ability to work effectively independently and collaboratively within a team.  Must be highly motivated, responsible, dependable, and a self-starter.
  8. Effective problem-solving skills; must demonstrate innovation and creativity, sound judgment, and good decision-making. 
  9. Good computer skills, including database management. Ability to learn new programs as needed. I
  10. Animal research only: Must demonstrate compliance with CWRU animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.
  11. Animal research only: Must demonstrate compassion for animals within CWRU facilities and dedication to the Animal Resource Center’s mission.  Must handle animals with care and respect at all times.
  12. Animal Research only: Must be able and willing to maintain a high standard of personal cleanliness and utilize protective gear to protect the health the animals.

 

WORKING CONDITIONS

The working conditions are typical of an office environment and computer rooms. There will be little to no exposure to hazards. The work requires negligible physical exertion, however, limited manual dexterity is required.

 

Animal research only: Case's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals."  This position, and all animal research personnel, are subject to internal compliance to SOM Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.

 

DIVERSITY STATEMENT

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity.  Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

 

Qualified candidates should send their cvs to satish.viswanath@case.edu & pxt130@case.edu