Research Associate (Laboratory Research) - Cancer Biology, Dept of Medicine

Date: December 13, 2021

Title: Research Associate (Laboratory Research)

Department: Cancer Biology, Dept of Medicine

School: Medicine

Location: MetroHealth Medical Center

Supervisor Name and Title: Chengfeng Yang, Ph.D., Professor (chengfeng.yang@case.edu)

 

POSITION OBJECTIVE

The Yang Lab focuses on studying the mechanism of cancer development, progression and developing new strategies to more efficiently prevent and treat cancer. The Research Associate will execute research projects with the aim of investigating the mechanism of lung cancer initiation and progression Under the guidance of the PI. The Research Associate is expected to work independently, design and plan projects, oversee collaborations, train students, technicians and postdocs, manage animal models, and carry out research activities of assigned projects through completion. The Research Associate will utilize modern cell biology and molecular biology techniques. The Research Associate will keep the PI informed of progress of research projects and provide recommendations on experimental design. The Research Associate will also present data and findings at lab and scientific meetings, seminars, etc., prepare manuscripts, and contribute preliminary data for grant proposals.  

 

ESSENTIAL FUNCTIONS 

Independent research: 

  1. Plan and execute experiments for research projects designed by the principal investigator and may design experiments independently and in collaboration with the PI. Assist with and coordinate experiments performed by other lab members, ensuring adequate resources, assisting with experimental design and analysis. Oversee progress of the research projects and provide regular progress reports to the PI; and provide input and recommendation to principal investigator regarding significant developments in research projects. Ensure the PI is informed about the results of lab members, and ensure the PI’s experimental strategy is explored by lab members and through independent experiments by the Research Associate. Maintain accurate records of data and provide findings and recommendations to the PI based on analysis. (70%)
  2. Collaborative research: Conduct experiments to supply scientific information as part of a larger project. Studies involve but are not limited to cell culture, Western blotting, ELISA, DNA and RNA isolation, PCR, IHC and IF staining, in vivo studies using animals, etc.) Maintain accurate records of data and provide findings and recommendations to the PI based on analysis. (10%)
  3. Assist the PI in and independently develop new techniques and protocols. Train lab members on new techniques. (2%) 
  4. Mentor and train lab staff and graduate students; oversee research work and ensure pro jects are being completed according to the research plan. This will involve teaching other members of the lab techniques and scientific discovery methods, including students and post-docs. Assist and teach both established and new research techniques to other lab members to facilitate their experiments. Coordinate trainings for lab members with the EHS and others, as needed. (3%)
  5. Present data and findings at laboratory meetings and scientific meetings, seminars, etc. Prepare manuscripts, and contribute preliminary data for grant proposals. (5%)  
  6. Independently author research projects. Assemble data and make publication-quality figures from analyzed data. With the highest level of integrity and responsible conduct of research, participate in writing manuscripts as a first author and co-author for discoveries from research performed in the lab, together with the PI and other lab members. (5%)
  7. Assess, update, and develop new standard operating procedures (SOPs) for the lab. (1%)
  8. Operate laboratory equipment such as fluorescence microscope, Q-PCR machine, Western blot imager, etc. Assist other lab members with general lab maintenance and help oversee and maintain inventory of scientific reagents. (2%) 

 

NONESSENTIAL FUNCTIONS

  1. Perform other duties as assigned. (2%)

 

CONTACTS 

Department: Frequent contact with PI and lab members, may work with other faculty for collaboration of research projects, contact with administrative staff as needed

University: Regular/Occasional contact with other labs for collaboration, Regular/Occasional contact with the Animal Resource Center, Contact with other departments as needed

External: Supply vendors, other institutions, funding agencies, etc. as needed

Students: Undergraduate and graduate student employees working in the lab

 

SUPERVISORY RESPONSIBILITY

No direct supervisory responsibilities. May train and provide oversight to lab staff and students.

 

QUALIFICATIONS 

Experience: Minimum of 3 to 5 years of related postdoctoral experience required. Experience in preferred fields (cell Biology, molecular biology, Biochemistry, cancer biology, immunology, toxicology) of study preferred. 

 

Education/Licensing: PhD, MD, or other terminal degree in cancer biology, immunology, toxicology or relevant disciplines.  

 

REQUIRED KNOWLEDGE, SKILLS and ABILITIES 

  1. Skills working with mice including but not limited to oral gavage, ip and sq injection, genotyping and maintaining genetically modified mouse lines.
  2. Modern cell biology and molecular neology skills including but not limited to cell culture, gene cloning, western blot, q-PCR, IHC and IF staining, ELISA, DNA and RNA methylation analysis, ChIP assay, immunoprecipitation and RNA immunoprecipitation,
  3. Excellent analytical skills; ability to formulate findings and recommendations from the analysis. 
  4. Excellent oral and written communication skills and interpersonal skills; must demonstrate the ability to effectively and professionally communicate and work with various individuals within and external to the University.
  5. Strong organization skills; ability to multi-task, prioritize, and meet deadlines.  Must demonstrate attention to detail and accuracy, time management skills, and follow-through. Must be able to work under pressure and conform to shifting priorities, demands, and timeline.    
  6. Effective leadership skills; ability to train, work with, and elicit cooperation from team members and staff.  
  7. Ability to work effectively independently and collaboratively within a team.  Must be highly motivated, responsible, dependable, and a self-starter. 
  8. Effective problem-solving skills; must demonstrate innovation and creativity, sound judgment, and good decision-making.  
  9. Good computer skills, including database management. Ability to learn new programs as needed.
  10. Animal research only: Must demonstrate compliance with CWRU animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.
  11. Animal research only: Must demonstrate compassion for animals within CWRU facilities and dedication to the Animal Resource Center’s mission.  Must handle animals with care and respect at all times.
  12. Animal Research only: Must be able and willing to maintain a high standard of personal cleanliness and utilize protective gear to protect the health the animals.

 

WORKING CONDITIONS 

 

Working in mouse room and general laboratory environment. May have exposure to hazards. May have to work overtime sometime. May have to travel for scientific meetings.

 

Animal research only: Case's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals."  This position, and all animal research personnel, are subject to internal compliance to SOM Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.

 

DIVERSITY STATEMENT

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity.  Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

 

Interested applicants should submit a complete CV, a cover letter of interest describing your research training/experience and future career goal and provide names/contact information of three individuals that can provide academic references upon request to: Dr. Chengfeng Yang 

(Chengfeng.yang@case.edu)