Date: September 2021
Title: Research Associate (Laboratory Research)
Location: Wood Research Tower, Biomedical Research Building.
Supervisor Name and Title: Danny Manor, Ph.D. Associate Professor
The Manor lab focuses on obtaining molecular-level understanding of pathologies that are common in Western society (cancer, obesity, cardiovascular disease, liver disease). The Research Associate will be involved in experimental design, execution and ensuing data analyses for research projects related to oncogene actions and/or vitamin E biology. Under the guidance of the PI, the Research Associate is expected to work independently, design, plan, execute and analyze experiments, oversee collaborations, supervise students, manage animal models, and carry out research activities of an assigned project through completion. The Research Associate will utilize standard cell biology, molecular biology, biochemistry, and genomic approaches as well experimentation in with whole animals. The Research Associate will meet with the PI daily and keep the PI informed of progress of research projects and provide recommendations on experimental design. The Research Associate will also present data and findings at lab and scientific meetings, seminars, prepare manuscripts, and contribute data for grant proposals.
- Plan and execute experiments for research projects designed by the principal investigator and may design experiments independently and in collaboration with the PI. Analyze and interpret experimental data. Assist with and coordinate experiments performed by other lab members, ensuring adequate resources, assisting with experimental design and analyses. Oversee progress of the research projects and provide regular progress reports to the PI; provide input and recommendation to principal investigator regarding significant developments in research projects. Ensure the PI is informed about the results of lab members, and ensure the PI’s experimental strategy is explored by lab members and through independent experiments by the Research Associate. Studies involve, but are not limited to, analysis of gene and protein expression, nucleic acid isolation, PCR and analyses, sterile tissue culture of immortalized and primary cells, animal genotyping, animal behavior experiments, analysis of tissues and cells from model animals. Maintain accurate records of data and provide findings and recommendations to the PI based on analysis. 70%
- Assist the PI and independently develop new experimental techniques and protocols needed for the project. Train lab members on techniques and instrumentation. 10%
- Mentor and train lab staff and graduate students; oversee research work and ensure projects are being completed according to the research plan. This will involve teaching other members of the lab techniques and scientific discovery methods, including students and post-docs. Assist and teach both established and new research techniques to other lab members to facilitate their experiments. Coordinate trainings for lab members with the EHS and others, as needed. 10%
- Present data and findings at laboratory meetings and scientific meetings, seminars, etc. Prepare manuscripts, and contribute preliminary data for grant proposals. 5%
- Independently write research manuscripts. Assemble data and make publication-quality figures from analyzed data. With the highest level of integrity and responsible conduct of research, participate in writing manuscripts as a first author and co-author for discoveries from research performed in the lab, together with the PI and other lab members. 5%
- Perform other duties as assigned.
Department: Frequent daily contact with PI and lab members, may work with other faculty for collaboration on research projects, contact with administrative staff as needed
University: Occasional contact with other labs for collaboration, Regular contact with the Animal Resource Center, Contact with other departments as needed
External: Supply vendors, other institutions, funding agencies, etc. as needed
Students: Undergraduate and graduate students and postdoc employees working in the lab
No direct supervisory responsibilities. Will train and provide oversight to lab staff and students.
Experience: Minimum of 3 to 7 years of related postdoctoral experience required. Experience in preferred field(s) of study preferred. Record of multiple first-author peer-reviewed publications.
Education/Licensing: PhD or MD in cell biology and animal models of disease.
REQUIRED KNOWLEDGE, SKILLS and ABILITIES
- Standard cell biology techniques (sterile culture of cells, transfections, recombinant DNA techniques).
- Standard Biochemistry techniques (PCR, immunoblotting, protein isolation and characterization)
- Characterization of animal models of human disease.
- Excellent analytical skills; ability to formulate findings and recommendations from the analysis.
- Excellent oral and written communication skills and interpersonal skills; must demonstrate the ability to effectively and professionally communicate and work with various individuals within and external to the University.
- Strong organizational skills; ability to multi-task, prioritize, and meet deadlines. Must demonstrate attention to detail and accuracy, time management skills, and follow-through. Must be able to work under pressure and conform to shifting priorities, demands, and timeline.
- Effective leadership skills; ability to lead, train, work with, and elicit cooperation from team members and staff.
- Ability to work effectively independently and collaboratively within a team. Must be highly motivated, responsible, dependable, and a self-starter.
- Effective problem-solving skills; must demonstrate innovation and creativity, sound judgment, and good decision-making.
- Good computer skills, including database management. Ability to learn new programs as needed.
- Must demonstrate compliance with CWRU animal research and care (ARC) policies and procedures and compliance to regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines and other applicable regulatory guidelines.
- Must demonstrate compassion for animals within CWRU facilities and dedication to the Animal Resource Center’s mission. Must handle animals with care and respect at all times.
- Must be able and willing to maintain a high standard of personal cleanliness and utilize protective gear to protect the health the animals.
General laboratory environment. May have exposure to hazards including paraformaldehyde, human and animal tissues and cells, general chemicals, and mice. Occasional overtime effort during evenings or weekends. Work with animals.
Case's animal facilities are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care (AAALAC) and is managed according to the "Guide for the Care and Use of Laboratory Animals” appropriate Federal Animal Welfare Regulations, and the Public Health Service “Policy on the Humane Care and Use of Laboratory Animals." This position, and all animal research personnel, are subject to internal compliance to SOM Animal Resource Center Standard Operating Procedures and to compliance regulations of the Animal Welfare Act, Public Health Service Policy, AAALAC guidelines, the State of Ohio Veterinary Practice Act, Federal Drug Enforcement Administration regulatory guidelines, US Food and Drug Administration Center for Veterinary Medicine regulations and other applicable regulatory guidelines.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Qualified applicants should send their cv to firstname.lastname@example.org