Research Associate - Specialized Technical Skills

Title: Research Associate, Specialized Technical Skills (STS)

Department: Population and Quantitative Health Science

School: School of Medicine

Location: WG-1

Supervisor Name and Title: Mark Cameron, PhD, Assistant Professor

 

POSITION OBJECTIVE

The Research Associate (RA) with Specialized Technical Skills (STS) will carry out analysis of genomic, transcriptomic, molecular and pathways studies in a systems biology laboratory with local and national collaborations in chronic human diseases, such as psoriasis and cancer. The responsibilities for this position include applying existing methods and pipelines, as well as developing new methods for analyzing genetic, genomic and systems data from studies of human disease, and where appropriate similar data from animal model studies. The successful candidates will conduct original research in development of assays and analytical methods. The positions involve collaborations locally, nationally and internationally, while presenting research results at national and international conferences and writing research papers and grants.

 

ESSENTIAL FUNCTIONS

  1. Manage and operate the laboratory and programs to support immunophenotyping, viral and transcriptomic workflows with a high degree of independence. 25%
  2. Design, manage, and perform highly specialized immunophenotyping, viral nucleic acid detection, and transcriptomic assays at the single cell level.  25% 
  3. Provide supervision and training of technical staff developing immunophenotyping and single cell protocols in immunobiological analysis.  15%
  4. Maintain biosafety and experimental protocols in cell biology, nucleic acid isolation, quality control/quality assurance to the laboratory and multidisciplinary programs focused on psoriasis and infectious disease (including emerging illness and HIV) vaccine and therapy research.  15%
  5. Apply knowledge of immunobiology and pathway biology to guide bioinformaticians in the analysis and interpretation of resulting datasets.  10%
  6. Contribute to research so as to merit serving as author or co-author on research publications.  10%

 

NONESSENTIAL FUNCTIONS

  1. Provide input and make recommendations to the principal investigator regarding significant developments in research projects within the lab and in the public domain.
  2. Ship, receive, process, inventory and biobank biological specimens and reagents.
  3. Assist with grants management to support the laboratory and workflows.
  4. Perform other duties as assigned. 

 

CONTACTS 

Department: Continuous contact with principal investigator, laboratory staff and postdocs.

University: Regular contact with purchasing, human resources, space and facilities planning, environmental health, safety/contact, Research Administration, IRB, and Sponsored Projects Accounting.  Frequent contact with collaborators in other university departments and centers.

External: Regular contact with vendors and collaborators at other national and international universities, institutions and industry.  Occasional contact with granting program directors and project managers. 

Students: Moderate contact as needed with students.

 

SUPERVISORY RESPONSIBILITY

Provide supervision, technical guidance and training of technical staff developing novel low-input (including single cell) protocols in next generation sequencing and bioinformatic analysis of the human and macaque genome and transcriptome.

 

QUALIFICATIONS

Experience: At least 5 years of experience in immunobiology and molecular techniques, QC, analysis and interpretation.

Education/Licensing: PhD preferred or BSc/MSc with equivalent specialized technical skills, in Biology, Systems Biology, Immunology

 

REQUIRED SKILLS

  1. Hands-on skills in SOPs and cellular and molecular biology, including flow analysis, nucleic acid isolation and amplification, and associated technology.
  2. Skills in quality control/quality assurance in laboratory and multidisciplinary programs in immunobiology
  3. Demonstrated skills in analytics, interpretation and visualization 
  4. Knowledge of genomics, proteomics, pathway and network analysis software and biology
  5. Demonstrated merit and collaborative skills in serving as author or co-author on research publications

 

WORKING CONDITIONS

Biosafety Level 2+ lab environment.  Hazards include: electrical currents, airborne or contact exposure to bacterial or viral materials, human and animal blood/blood products/biological samples/tissues, toxic or caustic chemicals, and explosive gases.

 

Interested candidates should send cv to Mark Cameron at mark.cameron@case.edu.