Medicine, Division of Infectious Diseases
School of Medicine
Case Main Campus, School of Medicine, BRB10
Supervisor Name and Title:
W. Henry Boom MD, Professor & Director, TB Research Unit
Working independently the research scientist will lead a research program within a TB research group directed by Dr. Boom on the molecular microbiology, drug resistance mechanisms and pathogenesis of M. tuberculosis and other mycobacteria with a focus in 3 areas: antimicrobial drug resistance mechanisms and potentiation of existing antibiotics for M. tuberculosis and M. abscessus, the function of the mycobacterial proteasome, the folate and folate-trap pathway in mycobacteria and the role of mycobacterial PKN-G in TB pathogenesis. In addition, the Research Scientist will provide leadership and supervision to graduate student(s), technician(s) and postdoctoral fellow(s) performing experiments in the above-described research areas. The Research Scientist will interact closely with the Principal Investigator and Supervisor as well as function in a highly independent manner. The research scientist will contribute to the data analysis of research results, write manuscripts and grant proposals.
Lead a research program within a TB research group led by Dr. Boom on the molecular microbiology and pathogenesis of M. tuberculosis and other mycobacteria with a focus in 3 areas: antimicrobial drug resistance and potentiation in M. tuberculosis and M. abscessus, the function of the mycobacterial proteasome, the folate and folate-trap pathway in mycobacteria and the role of mycobacterial PKN-G in pathogenesis. Conduct and supervise experiments. (45%)
Supervise the maintenance of clear and comprehensive records of experiments and manage data and protocols. Write manuscripts and research protocols with guidance from the supervisor (30%).
Coordinator activities of the laboratory and research staff. Supervise graduate students, postdoctoral fellows and technicians involved in the above research program. (10%)
Provide input and recommendations to the Principal Investigator regarding significant developments in research projects. Develop new laboratory protocols. (5%)
Perform complex quantitative analytical procedures using research data. (3%)
Train new staff. Teach and instruct others in research techniques (2%)
Co-lead with the supervisor weekly laboratory meetings. (2%)
Present progress at weekly laboratory meetings. (3%)
Department: Continuous contact with all members of the laboratory. Regular (weekly at a minimum) contact with the supervisor to provide research updates and plan future study activity.
University: Regular contact with collaborators within CWRU to present research progress. Regular contact with postdocs, technicians, and graduate students to direct research efforts and present at research conferences within CWRU.
External: Regular contact with outside collaborators to present research progress with the expectation to attend and present at research conferences outside of CWRU.
Students: Contact with graduate and undergraduate students to assure that they receive experimental support and training in the laboratory.
Direct supervisory responsibility for postdoc(s), graduate student(s) and technician(s) working in the Research Scientist’s laboratory program.
Experience: PhD in molecular microbiology of M. tuberculosis with more than 10 years of postdoctoral and/or faculty experience
Outstanding communication, organization and writing skills are required. The research environment requires a good balance between independence and teamwork. Good problem-solving and analytical skills are needed to accelerate data generation. Extensive experience performing and training personnel in the genetic manipulation of mycobacteria and testing of the resultant mutants (both gene deleted and re-constituted) for their biological function that includes biochemical, proteomic, and pathogenesis functions. Extensive experience working in and ideally some experience in managing a BSL3 facility for work with virulent and drug-resistant M. tuberculosis. Experience writing grants and manuscripts.
The research scientist will be working under BSL2 and BSL3 conditions with a biohazard, M. tuberculosis and will be expected to be experienced in working under these conditions with this pathogen. The research scientist will also be working where necessary with radioactive and toxic chemical materials within the limits and appropriate certified facilities as determined by DOES at CWRU.
A strong internal candidate has been identified.
Please send a copy of your CV with contact information and current publications as well as three professional references to Marla Manning at email@example.com.
In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.